Rodd_2022_Front.Behav.Neurosci_16_954319

Reference

Title : Negative and positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption - Rodd_2022_Front.Behav.Neurosci_16_954319
Author(s) : Rodd ZA , Swartzwelder HS , Waeiss RA , Soloviov SO , Lahiri DK , Engleman EA , Truitt WA , Bell RL , Hauser SR
Ref : Front Behavioral Neuroscience , 16 :954319 , 2022
Abstract :

Rationale and Objectives: Ethanol acts directly on the alpha7 Nicotinic acetylcholine receptor (alpha7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the alpha7 receptor regulates these damaging events. Administration of an alpha7 Negative Allosteric Modulator (NAM) or the cholinesterase inhibitor galantamine can prophylactically prevent adult consequences of ABAE. The goals of the experiments were to determine the effects of co-administration of ethanol and a alpha7 agonist in the mesolimbic dopamine system and to determine if administration of an alpha7 NAM or positive allosteric modulator (PAM) modulates the enhancement of adult alcohol drinking produced by ABAE. Methods: In adult rats, ethanol and the alpha7 agonist AR-R17779 (AR) were microinjected into the posterior ventral tegmental area (VTA), and dopamine levels were measured in the nucleus accumbens shell (AcbSh). In adolescence, rats were treated with the alpha7 NAM SB-277011-A (SB) or PNU-120596 (PAM) 2 h before administration of EtOH (ABAE). Ethanol consumption (acquisition, maintenance, and relapse) during adulthood was characterized. Results: Ethanol and AR co-administered into the posterior VTA stimulated dopamine release in the AcbSh in a synergistic manner. The increase in alcohol consumption during the acquisition and relapse drinking during adulthood following ABAE was prevented by administration of SB, or enhanced by administration of PNU, prior to EtOH exposure during adolescence. Discussion: Ethanol acts on the alpha7 receptor, and the alpha7 receptor regulates the critical effects of ethanol in the brain. The data replicate the findings that cholinergic agents (alpha7 NAMs) can act prophylactically to reduce the alterations in adult alcohol consumption following ABAE.

PubMedSearch : Rodd_2022_Front.Behav.Neurosci_16_954319
PubMedID: 37082421

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Citations formats

Rodd ZA, Swartzwelder HS, Waeiss RA, Soloviov SO, Lahiri DK, Engleman EA, Truitt WA, Bell RL, Hauser SR (2022)
Negative and positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption
Front Behavioral Neuroscience 16 :954319

Rodd ZA, Swartzwelder HS, Waeiss RA, Soloviov SO, Lahiri DK, Engleman EA, Truitt WA, Bell RL, Hauser SR (2022)
Front Behavioral Neuroscience 16 :954319