Lahiri DK

General

Full name : Lahiri Debomoy K

First name : Debomoy K

Mail : University School of Medicine 791 Union Drive, Indianapolis IN 46202

Zip Code :

City :

Country : USA

Email : dlahiri@iupui.edu

Phone : 317 274 2706

Fax : 317 274 1365

Website :

Directory :

References (39)

Title : Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders - Li_2024_Geroscience__
Author(s) : Li Y , Vaughan KL , Wang Y , Yu SJ , Bae EK , Tamargo IA , Kopp KO , Tweedie D , Chiang CC , Schmidt KT , Lahiri DK , Tones MA , Zaleska MM , Hoffer BJ , Mattison JA , Greig NH
Ref : Geroscience , : , 2024
PubMedID: 38532069

Title : Negative and positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption - Rodd_2022_Front.Behav.Neurosci_16_954319
Author(s) : Rodd ZA , Swartzwelder HS , Waeiss RA , Soloviov SO , Lahiri DK , Engleman EA , Truitt WA , Bell RL , Hauser SR
Ref : Front Behavioral Neuroscience , 16 :954319 , 2022
PubMedID: 37082421

Title : Rivastigmine modifies the alpha-secretase pathway and potentially early Alzheimer's disease - Ray_2020_Transl.Psychiatry_10_47
Author(s) : Ray B , Maloney B , Sambamurti K , Karnati HK , Nelson PT , Greig NH , Lahiri DK
Ref : Transl Psychiatry , 10 :47 , 2020
PubMedID: 32066688

Title : Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-beta Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer's Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway - Reale_2014_Curr.Alzheimer.Res_11_608
Author(s) : Reale M , Di Nicola M , Velluto L , D'Angelo C , Costantini E , Lahiri DK , Kamal MA , Yu QS , Greig NH
Ref : Curr Alzheimer Res , 11 :608 , 2014
PubMedID: 24359497

Title : Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, alpha -Synuclein Synthesis, Interleukin-1beta Release, and Cholinergic Action - Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117
Author(s) : Yu QS , Reale M , Kamal MA , Holloway HW , Luo W , Sambamurti K , Ray B , Lahiri DK , Rogers JT , Greig NH
Ref : Antiinflamm Antiallergy Agents Med Chem , 12 :117 , 2013
PubMedID: 23360256

Title : The aged garlic extract: (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD) - Ray_2011_Curr.Med.Chem_18_3306
Author(s) : Ray B , Chauhan NB , Lahiri DK
Ref : Curr Med Chem , 18 :3306 , 2011
PubMedID: 21728972

Title : Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model - Ray_2011_J.Neurochem_117_388
Author(s) : Ray B , Chauhan NB , Lahiri DK
Ref : Journal of Neurochemistry , 117 :388 , 2011
PubMedID: 21166677

Title : A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease - Bailey_2010_J.Neurochem_112_843
Author(s) : Bailey JA , Lahiri DK
Ref : Journal of Neurochemistry , 112 :843 , 2010
PubMedID: 19912467

Title : Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine - Yu_2010_Bioorg.Med.Chem_18_4687
Author(s) : Yu QS , Holloway HW , Luo W , Lahiri DK , Brossi A , Greig NH
Ref : Bioorganic & Medicinal Chemistry , 18 :4687 , 2010
PubMedID: 20627738

Title : The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice - Lahiri_2007_J.Pharmacol.Exp.Ther_320_386
Author(s) : Lahiri DK , Chen D , Maloney B , Holloway HW , Yu QS , Utsuki T , Giordano T , Sambamurti K , Greig NH
Ref : Journal of Pharmacology & Experimental Therapeutics , 320 :386 , 2007
PubMedID: 17003227

Title : Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease - Lahiri_2007_Neuromolecular.Med_9_157
Author(s) : Lahiri DK , Alley GM , Tweedie D , Chen D , Greig NH
Ref : Neuromolecular Med , 9 :157 , 2007
PubMedID: 17627035

Title : Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease - Rice_2007_J.Alzheimers.Dis_11_481
Author(s) : Rice SG , Nowak L , Duysen EG , Lockridge O , Lahiri DK , Reyes PF
Ref : J Alzheimers Dis , 11 :481 , 2007
PubMedID: 17656828

Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174
Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH
Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006
PubMedID: 16570913

Title : Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide - Utsuki_2006_J.Pharmacol.Exp.Ther_318_855
Author(s) : Utsuki T , Yu QS , Davidson D , Chen D , Holloway HW , Brossi A , Sambamurti K , Lahiri DK , Greig NH , Giordano T
Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :855 , 2006
PubMedID: 16690718

Title : High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression - Sokol_2006_J.Child.Neurol_21_444
Author(s) : Sokol DK , Chen D , Farlow MR , Dunn DW , Maloney B , Zimmer JA , Lahiri DK
Ref : Journal of Child Neurology , 21 :444 , 2006
PubMedID: 16948926

Title : Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases - Lahiri_2005_Ann.N.Y.Acad.Sci_1056_430
Author(s) : Lahiri DK , Chen DM , Lahiri P , Bondy S , Greig NH
Ref : Annals of the New York Academy of Sciences , 1056 :430 , 2005
PubMedID: 16387707

Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213
Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK
Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005
PubMedID: 16275899

Title : An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease - Greig_2005_Curr.Alzheimer.Res_2_281
Author(s) : Greig NH , Sambamurti K , Yu QS , Brossi A , Bruinsma GB , Lahiri DK
Ref : Curr Alzheimer Res , 2 :281 , 2005
PubMedID: 15974893

Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986
Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH
Ref : Journal of Medicinal Chemistry , 48 :986 , 2005
PubMedID: 15715468

Title : Poster (39) A new generation of cholinesterase inhibitors with amyloid-modifying properties. -
Author(s) : Lahiri DK , Ge YW , Sambamurti K , Utsuki T , Ingram DK , Farlow MR , Greig NH
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :341 , 2004
PubMedID:

Title : Poster (43) BChE inhibition as a treatment strategy for alzheimer's disease. -
Author(s) : Greig NH , Ingram DK , Yu QS , Holloway HW , Utsuki T , Brossi A , Sambamurti K , Lahiri DK
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :343 , 2004
PubMedID:

Title : Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents - Lahiri_2004_Curr.Pharm.Des_10_3111
Author(s) : Lahiri DK , Rogers JT , Greig NH , Sambamurti K
Ref : Curr Pharm Des , 10 :3111 , 2004
PubMedID: 15544501

Title : A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease - Lahiri_2003_Curr.Drug.Targets_4_97
Author(s) : Lahiri DK , Farlow MR , Sambamurti K , Greig NH , Giacobini E , Schneider LS
Ref : Curr Drug Targets , 4 :97 , 2003
PubMedID: 12558063

Title : Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer's disease -
Author(s) : Lahiri DK , Farlow MR
Ref : Evid Based Ment Health , 6 :94 , 2003
PubMedID: 12893805

Title : Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins - Lahiri_2002_Ann.N.Y.Acad.Sci_965_364
Author(s) : Lahiri DK , Utsuki T , Chen D , Farlow MR , Shoaib M , Ingram DK , Greig NH
Ref : Annals of the New York Academy of Sciences , 965 :364 , 2002
PubMedID: 12105112

Title : Butyrylcholinesterase: an important new target in Alzheimer's disease therapy - Greig_2002_Int.Psychogeriatr_14_77
Author(s) : Greig NH , Lahiri DK , Sambamurti K
Ref : Int Psychogeriatr , 14 :77 , 2002
PubMedID: 12636181

Title : A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase - Greig_2001_Curr.Med.Res.Opin_17_159
Author(s) : Greig NH , Utsuki T , Yu Q , Zhu X , Holloway HW , Perry T , Lee B , Ingram DK , Lahiri DK
Ref : Curr Med Res Opin , 17 :159 , 2001
PubMedID: 11900310

Title : Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development - Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605
Author(s) : Shaw KT , Utsuki T , Rogers J , Yu QS , Sambamurti K , Brossi A , Ge YW , Lahiri DK , Greig NH
Ref : Proc Natl Acad Sci U S A , 98 :7605 , 2001
PubMedID: 11404470

Title : Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease - Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60
Author(s) : Lahiri DK , Farlow MR , Hintz N , Utsuki T , Greig NH
Ref : Acta Neurologica Scandinavica Supplementum , 176 :60 , 2000
PubMedID: 11273593

Title : The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics - Greig_2000_Acta.Neurol.Scand.Suppl_176_74
Author(s) : Greig NH , De Micheli E , Holloway HW , Yu QS , Utsuki T , Perry TA , Brossi A , Ingram DK , Deutsch J , Lahiri DK , Soncrant TT
Ref : Acta Neurologica Scandinavica Supplementum , 176 :74 , 2000
PubMedID: 11261809

Title : Metrifonate treatment of AD: influence of APOE genotype - Farlow_1999_Neurology_53_2010
Author(s) : Farlow MR , Cyrus PA , Nadel A , Lahiri DK , Brashear A , Gulanski B
Ref : Neurology , 53 :2010 , 1999
PubMedID: 10599773

Title : The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells - Lahiri_1998_Brain.Res.Mol.Brain.Res_62_131
Author(s) : Lahiri DK , Farlow MR , Sambamurti K
Ref : Brain Research Mol Brain Res , 62 :131 , 1998
PubMedID: 9813282

Title : Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease - Farlow_1998_Neurology_50_669
Author(s) : Farlow MR , Lahiri DK , Poirier J , Davignon J , Schneider L , Hui SL
Ref : Neurology , 50 :669 , 1998
PubMedID: 9521254

Title : The effect of tacrine and leupeptin on the secretion of the beta- amyloid precursor protein in HeLa cells - Lahiri_1997_Life.Sci_61_1985
Author(s) : Lahiri DK , Farlow MR , Sambamurti K , Nall C
Ref : Life Sciences , 61 :1985 , 1997
PubMedID: 9366505

Title : Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures - Lahiri_1997_Ann.N.Y.Acad.Sci_826_416
Author(s) : Lahiri DK , Farlow MR , Nurnberger JI, Jr. , Greig NH
Ref : Annals of the New York Academy of Sciences , 826 :416 , 1997
PubMedID: 9329715

Title : Apolipoprotein E genotype and gender influence response to tacrine therapy - Farlow_1996_Ann.N.Y.Acad.Sci_802_101
Author(s) : Farlow MR , Lahiri DK , Poirier J , Davignon J , Hui S
Ref : Annals of the New York Academy of Sciences , 802 :101 , 1996
PubMedID: 8993489

Title : Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines - Lahiri_1996_J.Mol.Neurosci_7_41
Author(s) : Lahiri DK , Farlow MR
Ref : Journal of Molecular Neuroscience , 7 :41 , 1996
PubMedID: 8835781

Title : Reversibility of the effect of tacrine on the secretion of the beta-amyloid precursor protein in cultured cells - Lahiri_1994_Neurosci.Lett_181_149
Author(s) : Lahiri DK
Ref : Neuroscience Letters , 181 :149 , 1994
PubMedID: 7898757

Title : Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines - Lahiri_1994_J.Neurosci.Res_37_777
Author(s) : Lahiri DK , Lewis S , Farlow MR
Ref : Journal of Neuroscience Research , 37 :777 , 1994
PubMedID: 8046778