Rohlman_2011_Neurotoxicol_32_268

Reference

Title : Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure - Rohlman_2011_Neurotoxicol_32_268
Author(s) : Rohlman DS , Anger WK , Lein PJ
Ref : Neurotoxicology , 32 :268 , 2011
Abstract :

There is compelling evidence that adverse neurobehavioral effects are associated with occupational organophosphorous pesticide (OP) exposure in humans. Behavioral studies of pesticide applicators, greenhouse workers, agricultural workers and farm residents exposed repeatedly over months or years to low levels of OPs reveal a relatively consistent pattern of neurobehavioral deficits. However, only two studies have demonstrated a link between neurobehavioral performance and current biomarkers of OP exposure including blood cholinesterase (ChE) activity and urinary levels of OP metabolites. A variety of reasons may explain why so few studies have reported such correlations, including differing individual and group exposure histories, differing methodologies for assessing behavior and exposure, and lack of a reliable index of exposure. Alternatively, these data may suggest that current biomarkers (ChE, urine metabolites) are neither predictive nor diagnostic of the neurobehavioral effects of chronic OP pesticide exposures. This review focuses on the evidence that neurobehavioral performance deficits are associated with occupational OP pesticide exposure and concludes that research needs to return to the basics and rigorously test the relationships between neurobehavioral performance and both current (ChE and urine metabolites) and novel (e.g., inflammation and oxidative stress) biomarkers using human and animal models. The results of such studies are critically important because OP pesticides are widely and extensively used throughout the world, including situations where exposure controls and personal protective equipment are not routinely used.

PubMedSearch : Rohlman_2011_Neurotoxicol_32_268
PubMedID: 21182866

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Citations formats

Rohlman DS, Anger WK, Lein PJ (2011)
Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure
Neurotoxicology 32 :268

Rohlman DS, Anger WK, Lein PJ (2011)
Neurotoxicology 32 :268