| Title : Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent - Romanelli_1996_Chirality_8_579 |
| Author(s) : Romanelli MN , Bartolini A , Bertucci C , Dei S , Ghelardini C , Giovannini MG , Gualtieri F , Pepeu G , Scapecchi S , Teodori E |
| Ref : Chirality , 8 :579 , 1996 |
|
Abstract :
The enantiomers of 3-alpha-tropyl 2-(phenylthio)butyrate (SM32, 1) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing, and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-(+)-hyoscyamine. |
| PubMedSearch : Romanelli_1996_Chirality_8_579 |
| PubMedID: 9025257 |
Romanelli MN, Bartolini A, Bertucci C, Dei S, Ghelardini C, Giovannini MG, Gualtieri F, Pepeu G, Scapecchi S, Teodori E (1996)
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent
Chirality
8 :579
Romanelli MN, Bartolini A, Bertucci C, Dei S, Ghelardini C, Giovannini MG, Gualtieri F, Pepeu G, Scapecchi S, Teodori E (1996)
Chirality
8 :579