| Title : Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown alga Sargassum sagamianum - Ryu_2003_Arch.Pharm.Res_26_796 |
| Author(s) : Ryu G , Park SH , Kim ES , Choi BW , Ryu SY , Lee BH |
| Ref : Arch Pharm Res , 26 :796 , 2003 |
|
Abstract :
Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione and (5E,9E,13E)-6,10,4-trimethyl-pentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with IC50 values of 65.0 approximately 48.0 and 34.0 approximately 23.0 microM, respectively. |
| PubMedSearch : Ryu_2003_Arch.Pharm.Res_26_796 |
| PubMedID: 14609125 |
Ryu G, Park SH, Kim ES, Choi BW, Ryu SY, Lee BH (2003)
Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown alga Sargassum sagamianum
Arch Pharm Res
26 :796
Ryu G, Park SH, Kim ES, Choi BW, Ryu SY, Lee BH (2003)
Arch Pharm Res
26 :796