| Title : Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia - Saez-Valero_2003_Brain.Res.Mol.Brain.Res_117_240 |
| Author(s) : Saez-Valero J , Gonzalez-Garcia C , Cena V |
| Ref : Brain Research Mol Brain Res , 117 :240 , 2003 |
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Abstract :
Biochemical changes in rat brain acetylcholinesterase (AChE) activity and molecular isoform distribution were studied using the middle cerebral artery occlusion model. After 24 h of permanent focal ischemia, AChE specific activity from infarcted cortex was found to decrease compared with contralateral cortex. Also a decrease in the minor monomeric (G1) form of AChE is response to ischemia was observed. Ischemia-induced AChE decrease was partially diminished by pre-treatment with dizocilpine (MK-801), a neuroprotective NMDA receptor blocker. |
| PubMedSearch : Saez-Valero_2003_Brain.Res.Mol.Brain.Res_117_240 |
| PubMedID: 14559160 |
Saez-Valero J, Gonzalez-Garcia C, Cena V (2003)
Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia
Brain Research Mol Brain Res
117 :240
Saez-Valero J, Gonzalez-Garcia C, Cena V (2003)
Brain Research Mol Brain Res
117 :240