Samochocki_2000_Acta.Neurol.Scand.Suppl_176_68

Reference

Title : Galantamine is an allosterically potentiating ligand of the human alpha4\/beta2 nAChR - Samochocki_2000_Acta.Neurol.Scand.Suppl_176_68
Author(s) : Samochocki M , Zerlin M , Jostock R , Groot Kormelink PJ , Luyten WH , Albuquerque EX , Maelicke A
Ref : Acta Neurologica Scandinavica Supplementum , 176 :68 , 2000
Abstract :

Galantamine (Reminyl) is a novel drug treatment for mild to moderate Alzheimer's disease (AD). Originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (AChE), galantamine also acts as an allosterically potentiating ligand (APL) on nicotinic acetylcholine receptors (nAChR). Having previously established this second mode of action on nAChRs from murine brain, we demonstrate here the same action of galantamine on the most abundant nAChR in the human brain, the alpha4/beta2 subtype. This nAChR-sensitizing action is not a common property of all, or most, AChE inhibitors, as is shown by the absence of this effect for other therapeutically applied AChE inhibitors including tacrine, metrifonate, rivastigmine and donepezil. The possible benefits for therapy of AD of an APL action on nicotinic receptors is discussed.

PubMedSearch : Samochocki_2000_Acta.Neurol.Scand.Suppl_176_68
PubMedID: 11261808

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Citations formats

Samochocki M, Zerlin M, Jostock R, Groot Kormelink PJ, Luyten WH, Albuquerque EX, Maelicke A (2000)
Galantamine is an allosterically potentiating ligand of the human alpha4\/beta2 nAChR
Acta Neurologica Scandinavica Supplementum 176 :68

Samochocki M, Zerlin M, Jostock R, Groot Kormelink PJ, Luyten WH, Albuquerque EX, Maelicke A (2000)
Acta Neurologica Scandinavica Supplementum 176 :68