Schetinger_1999_Biochem.Mol.Biol.Int_47_473

Reference

Title : Pre-conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat - Schetinger_1999_Biochem.Mol.Biol.Int_47_473
Author(s) : Schetinger MR , Bonan CD , Frassetto SS , Wyse AT , Schierholt RC , Webber A , Dias RD , Sarkis JJ , Netto CA
Ref : Biochemistry & Molecular Biology International , 47 :473 , 1999
Abstract :

This study shows the effect of transient global cerebral ischemia (ISC) on hippocampal acetylcholinesterase (AChE) activity. Naive adult Wistar rats received either a brief (2 min) or a long (10 min) ischemic episode by the four-vessel occlusion method. Pre-conditioned rats received double ischemia: a 10 min episode inflicted 24 h after a 2 min event, a condition known to confer cytoprotection to CA1 pyramidal cells of hippocampus. 2 min of ischemia caused an increase in acetylcholinesterase activity both immediately and 30 min after the episode, however enzyme activity was significantly decreased after 24 h of reperfusion. 10 min of ischemia caused an increase in activity both 60 min and 24 h after ischemia. Conversely, pre-conditioned rats displayed lower activity both immediately and 60 min after ischemia. Our results suggest that: a) neuronal death, that follows 10 min of ischemia, is associated to a late increase in acetylcholinesterase activity; b) pre-conditioning is related to diminished acetylcholinesterase activity. This is in agreement with previous evidence that acetylcholinesterase inhibition and maintenance of acetylcholine levels are beneficial for cell surviving after cerebral ischemia.

PubMedSearch : Schetinger_1999_Biochem.Mol.Biol.Int_47_473
PubMedID: 10204084

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Citations formats

Schetinger MR, Bonan CD, Frassetto SS, Wyse AT, Schierholt RC, Webber A, Dias RD, Sarkis JJ, Netto CA (1999)
Pre-conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat
Biochemistry & Molecular Biology International 47 :473

Schetinger MR, Bonan CD, Frassetto SS, Wyse AT, Schierholt RC, Webber A, Dias RD, Sarkis JJ, Netto CA (1999)
Biochemistry & Molecular Biology International 47 :473