| Title : 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity - Scipione_2008_Bioorg.Med.Chem.Lett_18_309 |
| Author(s) : Scipione L , De Vita D , Musella A , Flammini L , Bertoni S , Barocelli E |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :309 , 2008 |
|
Abstract :
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats. |
| PubMedSearch : Scipione_2008_Bioorg.Med.Chem.Lett_18_309 |
| PubMedID: 18023348 |
| Chemical | 4-aminopyridine |
Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E (2008)
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Bioorganic & Medicinal Chemistry Lett
18 :309
Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E (2008)
Bioorganic & Medicinal Chemistry Lett
18 :309