Title : Characterization of anticholinesterase-active 3-alkylpyridinium polymers from the marine sponge Reniera sarai in aqueous solutions - Sepcic_1997_J.Nat.Prod_60_991 |
Author(s) : Sepcic K , Guella G , Mancini I , Pietra F , Serra MD , Menestrina G , Tubbs K , Macek P , Turk T |
Ref : Journal of Natural Products , 60 :991 , 1997 |
Abstract :
From the marine sponge Reniera sarai 3-alkylpyridinium oligomers and polymers have been isolated. 3-Alkylpyridinium polymers are potent anticholinesterase agents; in addition, they show hemolytic and cytotoxic activities. Oligomers with a molecular weight lower than 3000 Da do not possess any significant activity. We report structural characterization of 3-alkylpyridinium polymers and their behavior in aqueous solutions. We found that biologically active polymers are composed of head-to-tail 3-alkylpyridinium units. According to MALDI-TOF spectrometry two species of polymers exist, the smaller with a molecular weight of 5520 Da and the larger with a molecular weight of 18,900 Da. Both polymers are soluble only in water, while low molecular oligomers are readily soluble in organic solvents. Polymers form large water-dissolved supramolecular structures with an average hydrodynamic radius of 23 +/- 2 nm and, therefore, cannot be separated with size-exclusion chromatography. |
PubMedSearch : Sepcic_1997_J.Nat.Prod_60_991 |
PubMedID: 9358641 |
Inhibitor | 3-Alkylpyridinium-Polymers |
Sepcic K, Guella G, Mancini I, Pietra F, Serra MD, Menestrina G, Tubbs K, Macek P, Turk T (1997)
Characterization of anticholinesterase-active 3-alkylpyridinium polymers from the marine sponge Reniera sarai in aqueous solutions
Journal of Natural Products
60 :991
Sepcic K, Guella G, Mancini I, Pietra F, Serra MD, Menestrina G, Tubbs K, Macek P, Turk T (1997)
Journal of Natural Products
60 :991