| Title : Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring - Sha_2020_Sci.Total.Environ_752_141784 |
| Author(s) : Sha R , Chen Y , Wang Y , Luo Y , Liu Y , Ma Y , Li Y , Xu L , Xie HQ , Zhao B |
| Ref : Sci Total Environ , 752 :141784 , 2020 |
| Abstract : Emerging evidence suggests that perinatal dioxin exposure affects neurodevelopment and impairs multiple brain functions, including cognitive, language, learning and emotion, in the offspring. However, the impacts of gestational and lactational exposure to dioxin on behavior and related molecular events are still not fully understood. In this study, female C57BL/6J mice were orally administered three doses of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) (0.1 or 10 mug/kg body weight (bw)) during the pregnancy and lactation periods. The locomotion, exploration and anxiety-related behaviors were examined by an open field test of the young adult female offspring at postnatal day 68. We found that the maternal TCDD exposure, particularly at a low dose, increased movement ability, novelty-exploration and certain anxiety-related behaviors in the offspring. Such hyperactivity-like behaviors were accompanied by the upregulation of certain genes associated with cholinergic neurotransmission or synaptogenesis in the offspring brain. In accordance with the potential enhancement of cholinergic neurotransmission due to the gene upregulations, the enzymatic activity of acetylcholinesterase was decreased, which might lead to excess acetylcholine and consequent hyper-excitation at the synapses. Thus, we found that gestational and lactational TCDD exposure at low dose caused hyperactivity-like behaviors in young adult female offspring and speculated the enhancement of cholinergic neurotransmission and synaptogenesis as potential molecular events underlying the neurobehavioral effects. |
| ESTHER : Sha_2020_Sci.Total.Environ_752_141784 |
| PubMedSearch : Sha_2020_Sci.Total.Environ_752_141784 |
| PubMedID: 32889265 |
Sha R, Chen Y, Wang Y, Luo Y, Liu Y, Ma Y, Li Y, Xu L, Xie HQ, Zhao B (2020)
Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring
Sci Total Environ
752 :141784
Sha R, Chen Y, Wang Y, Luo Y, Liu Y, Ma Y, Li Y, Xu L, Xie HQ, Zhao B (2020)
Sci Total Environ
752 :141784