Sharifi-Rad_2020_J.Clin.Med_9_

Reference

Title : Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics - Sharifi-Rad_2020_J.Clin.Med_9_
Author(s) : Sharifi-Rad M , Lankatillake C , Dias DA , Docea AO , Mahomoodally MF , Lobine D , Chazot PL , Kurt B , Tumer TB , Moreira AC , Sharopov F , Martorell M , Martins N , Cho WC , Calina D , Sharifi-Rad J
Ref : J Clin Med , 9 : , 2020
Abstract :

Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article review the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

PubMedSearch : Sharifi-Rad_2020_J.Clin.Med_9_
PubMedID: 32276438

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Citations formats

Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, Chazot PL, Kurt B, Tumer TB, Moreira AC, Sharopov F, Martorell M, Martins N, Cho WC, Calina D, Sharifi-Rad J (2020)
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
J Clin Med 9 :

Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, Chazot PL, Kurt B, Tumer TB, Moreira AC, Sharopov F, Martorell M, Martins N, Cho WC, Calina D, Sharifi-Rad J (2020)
J Clin Med 9 :