| Title : 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity - Shen_2008_Bioorg.Med.Chem_16_7646 |
| Author(s) : Shen Y , Sheng R , Zhang J , He Q , Yang B , Hu Y |
| Ref : Bioorganic & Medicinal Chemistry , 16 :7646 , 2008 |
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Abstract :
As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized, and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were found to inhibit AChE in the nanomolar range. The optimum inhibitor 3g exhibited 34-fold increase in AChE inhibition than donepezil and displayed neuroprotective effect against H(2)O(2)-induced cell death. |
| PubMedSearch : Shen_2008_Bioorg.Med.Chem_16_7646 |
| PubMedID: 18662884 |
Shen Y, Sheng R, Zhang J, He Q, Yang B, Hu Y (2008)
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity
Bioorganic & Medicinal Chemistry
16 :7646
Shen Y, Sheng R, Zhang J, He Q, Yang B, Hu Y (2008)
Bioorganic & Medicinal Chemistry
16 :7646