Shimotori_2015_J.Oleo.Sci_64_561

Reference

Title : Combination of Novozym 435-catalyzed enantioselective hydrolysis and amidation for the preparation of optically active delta-hexadecalactone - Shimotori_2015_J.Oleo.Sci_64_561
Author(s) : Shimotori Y , Hoshi M , Miyakoshi T
Ref : J Oleo Sci , 64 :561 , 2015
Abstract :

A new enzymatic method for synthesis of enantiomerically enriched delta-hexadecalactone (3) based on the enzymatic kinetic resolution of N-methyl-5-acetoxyhexadecanamide (1) is described. A combination of lipase-catalyzed hydrolysis and amidation improved enantioselectivity. Lipase-catalyzed amidation was also investigated. Detailed screening of solvents and additive amines was performed. The addition of cyclohexylamine to lipase-catalyzed hydrolysis afforded the best results to give both enantiomers of 3 with more than 90% enantiomeric excess.

PubMedSearch : Shimotori_2015_J.Oleo.Sci_64_561
PubMedID: 25948138
Gene_locus related to this paper: canar-LipB

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Citations formats

Shimotori Y, Hoshi M, Miyakoshi T (2015)
Combination of Novozym 435-catalyzed enantioselective hydrolysis and amidation for the preparation of optically active delta-hexadecalactone
J Oleo Sci 64 :561

Shimotori Y, Hoshi M, Miyakoshi T (2015)
J Oleo Sci 64 :561