| Title : Acetylcholine receptor: covalent attachment of depolarizing groups at the active site - Silman_1969_Science_164_1420 |
| Author(s) : Silman I , Karlin A |
| Ref : Science , 164 :1420 , 1969 |
|
Abstract :
Following reduction of the acetylcholine receptor in the electroplax with dithiothreitol, the quaternary ammonium compounds bromoacetylcholine bromide and the p-nitrophenyl ester of (p-carboxyphenyl) trimethylammonium iodide react near the active site probably with a sulfhydryl group. The covalently attached quaternary ammonium moieties additionally interact with the active site noncovalently to activate the receptor and cause depolarization of the cell. |
| PubMedSearch : Silman_1969_Science_164_1420 |
| PubMedID: 5783718 |
Silman I, Karlin A (1969)
Acetylcholine receptor: covalent attachment of depolarizing groups at the active site
Science
164 :1420
Silman I, Karlin A (1969)
Science
164 :1420