| Title : The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors - Simons_2009_Bioorg.Med.Chem.Lett_19_654 |
| Author(s) : Simons LJ , Caprathe BW , Callahan M , Graham JM , Kimura T , Lai Y , LeVine H, 3rd , Lipinski W , Sakkab AT , Tasaki Y , Walker LC , Yasunaga T , Ye Y , Zhuang N , Augelli-Szafran CE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :654 , 2009 |
|
Abstract :
It is believed that beta-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify beta-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for beta-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed. |
| PubMedSearch : Simons_2009_Bioorg.Med.Chem.Lett_19_654 |
| PubMedID: 19121939 |
Simons LJ, Caprathe BW, Callahan M, Graham JM, Kimura T, Lai Y, LeVine H, 3rd, Lipinski W, Sakkab AT, Tasaki Y, Walker LC, Yasunaga T, Ye Y, Zhuang N, Augelli-Szafran CE (2009)
The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors
Bioorganic & Medicinal Chemistry Lett
19 :654
Simons LJ, Caprathe BW, Callahan M, Graham JM, Kimura T, Lai Y, LeVine H, 3rd, Lipinski W, Sakkab AT, Tasaki Y, Walker LC, Yasunaga T, Ye Y, Zhuang N, Augelli-Szafran CE (2009)
Bioorganic & Medicinal Chemistry Lett
19 :654