Singh_2018_Diabetes.Metab.Syndr_12_275

OBJECTIVES: The present study aims to evaluate the levels of HDL and Paraoxonase-1 (PON1) and their correlation in atherosclerotic patients with and without diabetic mellitus (DM) as well as in control subjects in Northern Indian population. MATERIALS AND METHODS: We analyzed lipid profiles and Serum PON1 levels by automated analyzer and ELISA, respectively. Study subjects (N=150) were divided in three groups; Group I: Atherosclerotic patients without DM (N=50), Group II: Atherosclerotic patients with DM (N=50); Group III: Controls (N=50). RESULTS: We found a significantly (p<0.0001) low levels of HDL-C in Group I (32.2+/-7.3) and Group II (36.9+/-11.5) as compared to Group III (41.0+/-7.1). PON-1 levels were also significantly lower in Group I (60.1+/-10.5) and Group II (50.0+/-13.9) when compared to Group III (95.0+/-12.0). We observed a significant correlation (r=0.59, p<0.001) between the levels of PON1 and HDL-C in study subjects. CONCLUSIONS: The reduced levels of HDL and PON-1 and their significant correlation in CAD patients may be associated with the pathogenesis of this disease. Considering HDL as a dependent variable, Paraoxonase-1 is the most important parameter contributing to the total variation in HDL in CAD.