| Title : Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases - Sokolova_2011_Bioorg.Med.Chem.Lett_21_7216 |
| Author(s) : Sokolova NV , Nenajdenko VG , Sokolov VB , Serebryakova OG , Makhaeva GF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :7216 , 2011 |
|
Abstract :
A modification of novel fluorinated organophosphorous compounds containing terminal alkyne group by different azidopeptides via Cu(I)-catalyzed click chemistry has been described. The inhibitor activity of trifluoromethyl-containing methylphosphonates and their peptide-conjugates towards acetylcholinesterase, butyrylcholinesterase, and carboxylesterase has been investigated. It was shown that the incorporation of peptide fragments significantly modulates the esterase profile of starting methylphosphonates. |
| PubMedSearch : Sokolova_2011_Bioorg.Med.Chem.Lett_21_7216 |
| PubMedID: 22001085 |
Sokolova NV, Nenajdenko VG, Sokolov VB, Serebryakova OG, Makhaeva GF (2011)
Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases
Bioorganic & Medicinal Chemistry Lett
21 :7216
Sokolova NV, Nenajdenko VG, Sokolov VB, Serebryakova OG, Makhaeva GF (2011)
Bioorganic & Medicinal Chemistry Lett
21 :7216