Makhaeva GF

General

Full name : Makhaeva Galina F

First name : Galina F

Mail : Institute of Physiologically Active Compounds Russian Acad Sci, Molecular Toxicology, 1 Severny proezd, Chernogolovka, 142432

Zip Code : 142432 Moscow Region

City : Moscow

Country : Russia

Email : gmakh@ipac.ac.ru

Phone : +74965242597

Fax :

Website :

Directory :

References (79)

Title : Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease - Makhaeva_2024_Molecules_29_321
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serkov IV , Proshin AN , Soldatova YV , Poletaeva DA , Faingold, II , Mumyatova VA , Terentiev AA , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ
Ref : Molecules , 29 :321 , 2024
PubMedID: 38257233

Title : Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease - Mezeiova_2024_Biomed.Pharmacother_173_116399
Author(s) : Mezeiova E , Prchal L , Hrabinova M , Muckova L , Pulkrabkova L , Soukup O , Misiachna A , Janousek J , Fibigar J , Kucera T , Horak M , Makhaeva GF , Korabecny J
Ref : Biomed Pharmacother , 173 :116399 , 2024
PubMedID: 38492439

Title : Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit beta-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease - Makhaeva_2023_Front.Pharmacol_14_1219980
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serebryakova OG , Shchepochkin AV , Averkov MA , Utepova IA , Demina NS , Radchenko EV , Palyulin VA , Fisenko VP , Bachurin SO , Chupakhin ON , Charushin VN , Richardson RJ
Ref : Front Pharmacol , 14 :1219980 , 2023
PubMedID: 37654616

Title : Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease - Makhaeva_2023_Int.J.Mol.Sci_24_2285
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Grishchenko MV , Lushchekina SV , Astakhova TY , Serebryakova OG , Timokhina EN , Zhilina EF , Shchegolkov EV , Ulitko MV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ
Ref : Int J Mol Sci , 24 :2285 , 2023
PubMedID: 36768608

Title : Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block beta-amyloid aggregation - Khudina_2023_Arch.Pharm.(Weinheim)__e2300447
Author(s) : Khudina OG , Grishchenko MV , Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Borisevich SS , Burgart YV , Saloutin VI , Charushin VN
Ref : Arch Pharm (Weinheim) , :e2300447 , 2023
PubMedID: 38072670

Title : New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones - Elkina_2022_Biomolecules_12_
Author(s) : Elkina NA , Grishchenko MV , Shchegolkov EV , Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Radchenko EV , Palyulin VA , Zhilina EF , Perminova AN , Lapshin LS , Burgart YV , Saloutin VI , Richardson RJ
Ref : Biomolecules , 12 : , 2022
PubMedID: 36358901

Title : Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals - Burgart_2022_Molecules_28_
Author(s) : Burgart YV , Elkina NA , Shchegolkov EV , Krasnykh OP , Makhaeva GF , Triandafilova GA , Solodnikov SY , Boltneva NP , Rudakova EV , Kovaleva NV , Serebryakova OG , Ulitko MV , Borisevich SS , Gerasimova NA , Evstigneeva NP , Kozlov SA , Korolkova YV , Minin AS , Belousova AV , Mozhaitsev ES , Klabukov AM , Saloutin VI
Ref : Molecules , 28 : , 2022
PubMedID: 36615256

Title : Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease - Bachurin_2022_Int.J.Mol.Sci_23_
Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Aksinenko AY , Grigoriev VV , Goreva TV , Epishina TA , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Vinogradova DV , Shevtsov PN , Pushkareva EA , Dubova LG , Serkova TP , Veselov IM , Fisenko VP , Richardson RJ
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36430413

Title : Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile - Makhaeva_2022_Molecules_27_
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Astakhova TY , Serkov IV , Proshin AN , Radchenko EV , Palyulin VA , Korabecny J , Soukup O , Bachurin SO , Richardson RJ
Ref : Molecules , 27 : , 2022
PubMedID: 35164325

Title : Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease - Grishchenko_2022_ChemMedChem__e202200080
Author(s) : Grishchenko MV , Makhaeva GF , Burgart YV , Rudakova EV , Boltneva NP , Kovaleva NV , Serebryakova OG , Lushchekina SV , Astakhova TY , Zhilina EF , Shchegolkov EV , Richardson RJ , Saloutin VI
Ref : ChemMedChem , :e202200080 , 2022
PubMedID: 35322571

Title : Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment - Makhaeva_2021_Bioorg.Chem_112_104974
Author(s) : Makhaeva GF , Lushchekina SV , Kovaleva NV , Yu Astakhova T , Boltneva NP , Rudakova EV , Serebryakova OG , Proshin AN , Serkov IV , Trofimova TP , Tafeenko VA , Radchenko EV , Palyulin VA , Fisenko VP , Korabecny J , Soukup O , Richardson RJ
Ref : Bioorg Chem , 112 :104974 , 2021
PubMedID: 34029971

Title : Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold - Makhaeva_2021_Eur.J.Med.Chem_218_113385
Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Kovaleva NV , Rudakova EV , Elkina NA , Shchegolkov EV , Burgart YV , Stupina TS , Terentiev AA , Radchenko EV , Palyulin VA , Saloutin VI , Bachurin SO , Richardson RJ
Ref : Eur Journal of Medicinal Chemistry , 218 :113385 , 2021
PubMedID: 33831780

Title : Conjugation of Aminoadamantane and gamma-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands - Bachurin_2021_Molecules_26_
Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Aksinenko AY , Grigoriev VV , Shevtsov PN , Goreva TV , Epishina TA , Kovaleva NV , Pushkareva EA , Boltneva NP , Lushchekina SV , Gabrelyan AV , Zamoyski VL , Dubova LG , Rudakova EV , Fisenko VP , Bovina EV , Richardson RJ
Ref : Molecules , 26 : , 2021
PubMedID: 34576998

Title : Neuropathy target esterase (NTE\/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN) - Richardson_2020_Adv.Neurotoxicol_4_1
Author(s) : Richardson RJ , Fink JK , Glynn P , Hufnagel RB , Makhaeva GF , Wijeyesakere SJ
Ref : Adv Neurotoxicol , 4 :1 , 2020
PubMedID: 32518884

Title : Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System - Akimov_2020_Biomolecules_10_
Author(s) : Akimov MG , Kudryavtsev DS , Kryukova EV , Fomina-Ageeva EV , Zakharov SS , Gretskaya NM , Zinchenko GN , Serkov IV , Makhaeva GF , Boltneva NP , Kovaleva NV , Serebryakova OG , Lushchekina SV , Palikov VA , Palikova Y , Dyachenko IA , Kasheverov IE , Tsetlin VI , Bezuglov VV
Ref : Biomolecules , 10 : , 2020
PubMedID: 32059521

Title : New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_5891
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Faingold, II , Poletaeva DA , Soldatova YV , Kotelnikova RA , Serkov IV , Ustinov AK , Proshin AN , Radchenko EV , Palyulin VA , Richardson RJ
Ref : Molecules , 25 :5891 , 2020
PubMedID: 33322783

Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ
Ref : Molecules , 25 :3915 , 2020
PubMedID: 32867324

Title : Overview of novel multifunctional agents based on conjugates of gamma-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease - Makhaeva_2019_Chem.Biol.Interact_13ChEPon_308_224
Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Lushchekina SV , Kovaleva NV , Rudakova EV , Bachurin SO , Richardson RJ
Ref : Chemico-Biological Interactions , 308 :224 , 2019
PubMedID: 31100279

Title : Conjugates of methylene blue with gamma-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases - Bachurin_2019_Sci.Rep_9_4873
Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Lushchekina SV , Rudakova EV , Dubova LG , Vinogradova DV , Sokolov VB , Aksinenko AY , Fisenko VP , Richardson RJ , Aliev G
Ref : Sci Rep , 9 :4873 , 2019
PubMedID: 30890752

Title : Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers - Khudina_2019_Bioorg.Med.Chem.Lett__126716
Author(s) : Khudina OG , Makhaeva GF , Elkina NA , Boltneva NP , Serebryakova OG , Shchegolkov EV , Rudakova EV , Lushchekina SV , Burgart YV , Bachurin SO , Richardson RJ , Saloutin VI
Ref : Bioorganic & Medicinal Chemistry Lett , :126716 , 2019
PubMedID: 31640885

Title : Anticholinesterase and Antioxidant Activity of New Binary Conjugates of gamma-Carbolines - Makhaeva_2019_Dokl.Biochem.Biophys_484_1
Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Rudakova EV , Dubova LG , Shevtsov PN , Bachurin SO
Ref : Dokl Biochem Biophys , 484 :1 , 2019
PubMedID: 31012000

Title : Cholinesterase and carboxylesterase inhibitors as pharmacological agents - Makhaeva_2019_Russ Chem Bull_68_967
Author(s) : Makhaeva GF , Rudakova EV , Kovaleva NV , Lushchekina SV , Boltneva NP , Proshin AN , Shchegolkov EV , Burgart YV , Saloutin VI
Ref : Russ Chem Bull , 68 :967 , 2019
PubMedID:

Title : Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors - Makhaeva_2019_Bioorg.Chem_91_103097
Author(s) : Makhaeva GF , Elkina NA , Shchegolkov EV , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ
Ref : Bioorg Chem , 91 :103097 , 2019
PubMedID: 31323527

Title : Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation - Makhaeva_2019_Bioorg.Chem__103387
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Stupina TS , Terentiev AA , Serkov IV , Proshin AN , Radchenko EV , Palyulin VV , Bachurin SO , Richardson RJ
Ref : Bioorg Chem , :103387 , 2019
PubMedID: 31735356

Title : Conjugates of Tacrine and Its Cyclic Homologues with p-Toluenesulfonamide as Novel Acetylcholinesterase and Butyrylcholinesterase Inhibitors - Makhaeva_2018_Dokl.Biochem.Biophys_483_369
Author(s) : Makhaeva GF , Kovaleva NV , Lushchekina SV , Rudakova EV , Boltneva NP , Proshin AN , Lednev BV , Serkov IV , Bachurin SO
Ref : Dokl Biochem Biophys , 483 :369 , 2018
PubMedID: 30607741

Title : Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics - Makhaeva_2018_Bioorg.Med.Chem_26_4716
Author(s) : Makhaeva GF , Boltneva NP , Lushchekina SV , Rudakova EV , Serebryakova OG , Kulikova LN , Beloglazkin AA , Borisov RS , Richardson RJ
Ref : Bioorganic & Medicinal Chemistry , 26 :4716 , 2018
PubMedID: 30104121

Title : 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment - Makhaeva_2017_Bioorg.Med.Chem_25_5981
Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Rudakova EV , Ustyugov AA , Bachurin SO , Shchepochkin AV , Chupakhin ON , Charushin VN , Richardson RJ
Ref : Bioorganic & Medicinal Chemistry , 25 :5981 , 2017
PubMedID: 28986116

Title : Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment - Bachurin_2017_Sci.Rep_7_45627
Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Grigoriev VV , Boltneva NP , Kovaleva NV , Lushchekina SV , Shevtsov PN , Neganova ME , Redkozubova OM , Bovina EV , Gabrelyan AV , Fisenko VP , Sokolov VB , Aksinenko AY , Echeverria V , Barreto GE , Aliev G
Ref : Sci Rep , 7 :45627 , 2017
PubMedID: 28358144

Title : Novel conjugates of tacrine with 1,2,4,-thiadiazole as highly effective cholinesterase inhibitors, blockers of NMDA receptors, and antioxidants - Makhaeva_2017_Dokl.Biochem.Biophys_477_405
Author(s) : Makhaeva GF , Grigoriev VV , Proshin AN , Kovaleva NV , Rudakova EV , Boltneva NP , Serkov IV , Bachurin SO
Ref : Dokl Biochem Biophys , 477 :405 , 2017
PubMedID: 29297118

Title : Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors - Shchegol'kov_2017_Bioorg.Med.Chem_25_3997
Author(s) : Shchegol'kov EV , Makhaeva GF , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Burgart YV , Saloutin VI , Chupakhin ON , Bachurin SO , Richardson RJ
Ref : Bioorganic & Medicinal Chemistry , 25 :3997 , 2017
PubMedID: 28578994

Title : Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo - Makhaeva_2016_Chem.Biol.Interact_259_332
Author(s) : Makhaeva GF , Rudakova EV , Serebryakova OG , Aksinenko AY , Lushchekina SV , Bachurin SO , Richardson RJ
Ref : Chemico-Biological Interactions , 259 :332 , 2016
PubMedID: 27154493

Title : Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors - Makhaeva_2016_Bioorg.Med.Chem_24_1050
Author(s) : Makhaeva GF , Boltneva NP , Lushchekina SV , Serebryakova OG , Stupina TS , Terentiev AA , Serkov IV , Proshin AN , Bachurin SO , Richardson RJ
Ref : Bioorganic & Medicinal Chemistry , 24 :1050 , 2016
PubMedID: 26827140

Title : Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds - Makhaeva_2016_J.Appl.Toxicol_36_1468
Author(s) : Makhaeva GF , Rudakova EV , Sigolaeva LV , Kurochkin IN , Richardson RJ
Ref : J Appl Toxicol , 36 :1468 , 2016
PubMedID: 26970094

Title : Alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates as new effective and selective inhibitors of carboxylesterase - Boltneva_2015_Dokl.Biochem.Biophys_465_381
Author(s) : Boltneva NP , Makhaeva GF , Kovaleva NV , Lushchekina SV , Burgart YV , Shchegol'kov EV , Saloutin VI , Chupakhin ON
Ref : Dokl Biochem Biophys , 465 :381 , 2015
PubMedID: 26728730

Title : Conjugates of gamma-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease - Makhaeva_2015_Sci.Rep_5_13164
Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Sokolov VB , Grigoriev VV , Serebryakova OG , Vikhareva EA , Aksinenko AY , Barreto GE , Aliev G , Bachurin SO
Ref : Sci Rep , 5 :13164 , 2015
PubMedID: 26281952

Title : Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds - Makhaeva_2014_J.Appl.Toxicol_34_1426
Author(s) : Makhaeva GF , Rudakova EV , Hein ND , Serebryakova OG , Kovaleva NV , Boltneva NP , Fink JK , Richardson RJ
Ref : J Appl Toxicol , 34 :1426 , 2014
PubMedID: 24395470

Title : Neuropathy target esterase (NTE): overview and future - Richardson_2013_Chem.Biol.Interact_203_238
Author(s) : Richardson RJ , Hein ND , Wijeyesakere SJ , Fink JK , Makhaeva GF
Ref : Chemico-Biological Interactions , 203 :238 , 2013
PubMedID: 23220002

Title : Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects - Makhaeva_2013_Chem.Biol.Interact_203_231
Author(s) : Makhaeva GF , Radchenko EV , Palyulin VA , Rudakova EV , Aksinenko AY , Sokolov VB , Zefirov NS , Richardson RJ
Ref : Chemico-Biological Interactions , 203 :231 , 2013
PubMedID: 23123251

Title : A new selective inhibitor of mouse blood plasma carboxylesterase -
Author(s) : Rudakova EV , Makhaeva GF , Galenko TG , Aksinenko AY , Sokolov VB , Martynov IV
Ref : Dokl Biochem Biophys , 449 :87 , 2013
PubMedID: 23657654

Title : N,N-disubstituted 2-aminothiazolines as new inhibitors of serine esterases -
Author(s) : Boltneva NP , Serebryakova OG , Makhaeva GF , Serkov IV , Proshin AN , Bachurin SO
Ref : Dokl Biochem Biophys , 451 :209 , 2013
PubMedID: 23975403

Title : Kinetics and mechanism of inhibition of serine esterases by fluorinated carbethoxy 1-aminophosphonates -
Author(s) : Makhaeva GF , Lushchekina SV , Serebryakova OG , Aksinenko AY , Goreva TV , Richardson RJ , Martynov IV
Ref : Dokl Biochem Biophys , 451 :203 , 2013
PubMedID: 23975401

Title : Determination of binding points of methylene blue and cationic phenoxazine dyes on human butyrylcholinesterase - Sezgin_2013_Arch.Biochem.Biophys_532_32
Author(s) : Sezgin Z , Biberoglu K , Chupakhin V , Makhaeva GF , Tacal O
Ref : Archives of Biochemistry & Biophysics , 532 :32 , 2013
PubMedID: 23353050

Title : Synthesis and biological activity of O-carbamoylated 1,1,1,3,3,3-hexafluoroisopropanols as new specific inhibitors of carboxylesterase - Mukhamadieva_2012_Pharm.Chem.J_46_461
Author(s) : Mukhamadieva GR , Boltneva NP , Galenko TG , Sokolov VB , Epishina TA , Makhaeva GF
Ref : Pharmaceutical Chemistry Journal , 46 :461 , 2012
PubMedID:

Title : Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism and Alzheimer's disease - Makhaeva_2012_SAR.QSAR.Environ.Res_23_627
Author(s) : Makhaeva GF , Radchenko EV , Baskin II , Palyulin VA , Richardson RJ , Zefirov NS
Ref : SAR QSAR Environ Research , 23 :627 , 2012
PubMedID: 22587543

Title : Molecular design of O-phosphorylated oximes--selective inhibitors of butyrylcholinesterase -
Author(s) : Radchenko EV , Mel'nikov AA , Makhaeva GF , Palyulin VA , Zefirov NS
Ref : Dokl Biochem Biophys , 443 :91 , 2012
PubMedID: 22562633

Title : Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects -
Author(s) : Rudakova EV , Makhaeva GF , Galenko TG , Aksinenko AY , Sokolov VB , Richardson RJ , Martynov IV
Ref : Dokl Biochem Biophys , 443 :81 , 2012
PubMedID: 22562631

Title : Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases - Sokolova_2011_Bioorg.Med.Chem.Lett_21_7216
Author(s) : Sokolova NV , Nenajdenko VG , Sokolov VB , Serebryakova OG , Makhaeva GF
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :7216 , 2011
PubMedID: 22001085

Title : Comparative analysis of esterase activities of human, mouse, and rat blood - Rudakova_2011_Bull.Exp.Biol.Med_152_73
Author(s) : Rudakova EV , Boltneva NP , Makhaeva GF
Ref : Bulletin of Experimental Biology & Medicine , 152 :73 , 2011
PubMedID: 22803044

Title : Biosensor analysis of blood esterases for organophosphorus compounds exposure assessment: approaches to simultaneous determination of several esterases - Sigolaeva_2010_Chem.Biol.Interact_187_312
Author(s) : Sigolaeva LV , Makhaeva GF , Rudakova EV , Boltneva NP , Porus M , Dubacheva G , Eremenko A , Kurochkin I , Richardson RJ
Ref : Chemico-Biological Interactions , 187 :312 , 2010
PubMedID: 20097186

Title : Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates - Makhaeva_2010_Chem.Biol.Interact_187_177
Author(s) : Makhaeva GF , Aksinenko AY , Sokolov VB , Baskin, II , Palyulin VA , Zefirov NS , Hein ND , Kampf JW , Wijeyesakere SJ , Richardson RJ
Ref : Chemico-Biological Interactions , 187 :177 , 2010
PubMedID: 20035729

Title : Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics - Makhaeva_2009_Bioorg.Med.Chem.Lett_19_5528
Author(s) : Makhaeva GF , Aksinenko AY , Sokolov VB , Serebryakova OG , Richardson RJ
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :5528 , 2009
PubMedID: 19717305

Title : Study of the structural determinants of acute and delayed neurotoxicity of O-phosphorylated oximes by molecular field topology analysis (MFTA) -
Author(s) : Radchenko EV , Makhaeva GF , Sokolov VB , Palyulin VA , Zefirov NS
Ref : Dokl Biochem Biophys , 429 :309 , 2009
PubMedID: 20101827

Title : Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols -
Author(s) : Makhaeva GF , Serebryakova OG , Boltneva NP , Galenko TG , Aksinenko AY , Sokolov VB , Martynov IV
Ref : Dokl Biochem Biophys , 423 :352 , 2008
PubMedID: 19230387

Title : Modeling of the relationships between the structure of O-phosphorylated oximes and their anticholinesterase activity and selectivity using molecular field topology analysis (MFTA) -
Author(s) : Radchenko EV , Makhaeva GF , Malygin VV , Sokolov VB , Palyulin VA , Zefirov NS
Ref : Dokl Biochem Biophys , 418 :47 , 2008
PubMedID: 18429606

Title : Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate - Wijeyesakere_2008_Acta.Crystallogr.Sect.E.Struct.Rep.Online_64_o1425
Author(s) : Wijeyesakere SJ , Nasser FA , Kampf JW , Aksinenko AY , Sokolov VB , Malygin VV , Makhaeva GF , Richardson RJ
Ref : Acta Crystallographica Sect E Struct Rep Online , 64 :o1425 , 2008
PubMedID: 19079747

Title : Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress - Makhaeva_2007_Hum.Exp.Toxicol_26_273
Author(s) : Makhaeva GF , Malygin VV , Strakhova NN , Sigolaeva LV , Sokolovskaya LG , Eremenko AV , Kurochkin IN , Richardson RJ
Ref : Hum Exp Toxicol , 26 :273 , 2007
PubMedID: 17615108

Title : Fluorinated alpha-aminophosphonates--a new type of irreversible inhibitors of serine hydrolases -
Author(s) : Makhaeva GF , Malygin VV , Aksinenko AY , Sokolov VB , Strakhova NN , Rasdolsky AN , Richardson RJ , Martynov IV
Ref : Dokl Biochem Biophys , 400 :92 , 2005
PubMedID: 15846994

Title : Improved electrochemical analysis of neuropathy target esterase activity by a tyrosinase carbon paste electrode modified by 1-methoxyphenazine methosulfate - Sokolovskaya_2005_Biotechnol.Lett_27_1211
Author(s) : Sokolovskaya LG , Sigolaeva LV , Eremenko AV , Gachok IV , Makhaeva GF , Strakhova NN , Malygin VV , Richardson RJ , Kurochkin IN
Ref : Biotechnol Lett , 27 :1211 , 2005
PubMedID: 16158266

Title : Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds - Makhaeva_2003_J.Toxicol.Environ.Health.A_66_599
Author(s) : Makhaeva GF , Sigolaeva LV , Zhuravleva LV , Eremenko AV , Kurochkin IN , Malygin VV , Richardson RJ
Ref : J Toxicol Environ Health A , 66 :599 , 2003
PubMedID: 12746135

Title : Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates - Malygin_2003_J.Toxicol.Environ.Health.A_66_611
Author(s) : Malygin VV , Sokolov VB , Richardson RJ , Makhaeva GF
Ref : J Toxicol Environ Health A , 66 :611 , 2003
PubMedID: 12746136

Title : Bioelectrochemical analysis of neuropathy target esterase activity in blood - Sigolaeva_2001_Anal.Biochem_290_1
Author(s) : Sigolaeva LV , Makower A , Eremenko AV , Makhaeva GF , Malygin VV , Kurochkin IN , Scheller FW
Ref : Analytical Biochemistry , 290 :1 , 2001
PubMedID: 11180931

Title : Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain -
Author(s) : Makhaeva GF , Malygin VV , Martynov IV
Ref : Dokl Biochem Biophys , 377 :68 , 2001
PubMedID: 11712153

Title : A stable preparation of hen brain neuropathy target esterase for rapid biochemical assessment of neurotoxic potential of organophosphates - Makhaeva_1999_Chem.Biol.Interact_119-120_551
Author(s) : Makhaeva GF , Malygin VV
Ref : Chemico-Biological Interactions , 119-120 :551 , 1999
PubMedID: 10421494

Title : A new approach for determination of neuropathy target esterase activity - Sigolaeva_1999_Chem.Biol.Interact_119-120_559
Author(s) : Sigolaeva LV , Eremenko AV , Makower A , Makhaeva GF , Malygin VV , Kurochkin IN
Ref : Chemico-Biological Interactions , 119-120 :559 , 1999
PubMedID: 10421495

Title : [Antiesterase activity and toxicity of O,O-dialkyl-S-ethoxycarbonylbromomethylthiophosphates] - Makhaeva_1999_Bioorg.Khim_25_8
Author(s) : Makhaeva GF , Iankovskaia VL , Kovaleva NV , Fetisov VI , Malygin VV , Torgasheva NA , Khaskin BA
Ref : Bioorganicheskaia Khimiia , 25 :8 , 1999
PubMedID: 10234440

Title : [O,O-dialkyl-S-bromomethylthiophosphates--inhibitors of mammalian choline- and carboxyl esterases: structure-activity relationship] - Makhaeva_1999_Bioorg.Khim_25_3
Author(s) : Makhaeva GF , Iankovskaia VL , Kovaleva NV , Fetisov VI , Malygin VV , Torgasheva NA , Khaskin BA
Ref : Bioorganicheskaia Khimiia , 25 :3 , 1999
PubMedID: 10234439

Title : [Mechanism of action of 2-aryloxy-2-thio-1,3,2-oxazaphosphorinane pesticides] - Shipov_1999_Bioorg.Khim_25_14
Author(s) : Shipov AE , Genkina GK , Makhaeva GF , Malygin VV , Volkova RI , Roslavtseva SA , Eremina O , Bakanova EI , Mastriukova TA , Kabachnik MI
Ref : Bioorganicheskaia Khimiia , 25 :14 , 1999
PubMedID: 10234441

Title : Comparative studies of O,O-dialkyl-O-chloromethylchloroformimino phosphates: interaction with neuropathy target esterase and acetylcholinesterase - Makhaeva_1998_Neurotoxicol_19_623
Author(s) : Makhaeva GF , Filonenko IV , Yankovskaya VL , Fomicheva SB , Malygin VV
Ref : Neurotoxicology , 19 :623 , 1998
PubMedID: 9745921

Title : [A comparative study of the interaction of phosphoric acid dichlorovinyl esters with a neurotoxic esterase from the brain of hens and rats] - Makhaeva_1995_Zh.Evol.Biokhim.Fiziol_31_396
Author(s) : Makhaeva GF , Filonenko IV , Malygin VV
Ref : Zhurnal Evoliutsionnoi Biokhimii i Fiziologii , 31 :396 , 1995
PubMedID: 8779279

Title : [Mechanism of action of thiophosphoroorganic insectoacaricides containing fragments of N-carbaalkoxylated amino acids] - Shipov_1995_Bioorg.Khim_21_235
Author(s) : Shipov AE , Genkina GK , Zhdanova GV , Makhaeva GF , Malygin VV , Volkova RI , Maizel EV , Sundukov OV , Mastriukova TA , Kabachnik MI
Ref : Bioorganicheskaia Khimiia , 21 :235 , 1995
PubMedID: 7763321

Title : [Similar sensitivity of neurotoxic esterase from rat and chicken brain to the effect of o-alkyl-o-alkylchloroformiminophenylphosphonates] -
Author(s) : Makhaeva GF , Filonenko IV , Malygin VV , Martynov IV
Ref : Doklady Akademii Nauk , 332 :650 , 1993
PubMedID: 8260929

Title : Poster: Phosphorylated alkylchloroformoximes as inhibitors of mammalian cholin- and carboxylesterases. Structure - activity relationships -
Author(s) : Makhaeva GF , Yankovskaya VL , Malyginin V , Sokolov VB , Martynov IV
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :290 , 1991
PubMedID:

Title : [O-alkyl-O-methylchlorformiminophenylphosphonates--effective inhibitors of neurotoxic esterases in chicken brains] -
Author(s) : Makhaeva GF , Kononova IV , Malygin VV , Liashenko Iu E , Sokolov VB , Martynov IV
Ref : Doklady Akademii Nauk SSSR , 317 :1009 , 1991
PubMedID: 1954851

Title : [Comparative study of the interaction of acetylcholinesterases of human erythrocytes and the heads of houseflies with phosphorylated alkylchloroformoximes] - Shataeva_1988_Zh.Evol.Biokhim.Fiziol_24_791
Author(s) : Shataeva GA , Makhaeva GF , Iankovskaia VL , Sokolov VB , Ivanov AN
Ref : Zhurnal Evoliutsionnoi Biokhimii i Fiziologii , 24 :791 , 1988
PubMedID: 3245355

Title : [Interaction of dialkyl(alpha-carbomethoxy-beta,beta,beta-trifluoro- ethyl) phosphates with mammalian esterases] - Makhaeva_1987_Bioorg.Khim_13_33
Author(s) : Makhaeva GF , Fetisov VI , Sokolov VB , Iankovskaia VL , Goreva TV
Ref : Bioorganicheskaia Khimiia , 13 :33 , 1987
PubMedID: 3566818

Title : [The role of esterases in the toxicity of organothiophosphorus insectoacaricides containing a fragment of mercaptoacetic acid] - Makhaeva_1985_Bioorg.Khim_11_957
Author(s) : Makhaeva GF , Iankovskaia VL , Odoeva GA , Shestakova NN , Khovanskikh AE
Ref : Bioorganicheskaia Khimiia , 11 :957 , 1985
PubMedID: 4052120

Title : [Nonlinear hydrophobicity-antiesterase activity model for various types of organophosphorous compounds] - Fetisov_1984_Bioorg.Khim_10_1353
Author(s) : Fetisov VI , Makhaeva GF , Loshadkin NA , Martynov IV , Khaskin BA
Ref : Bioorganicheskaia Khimiia , 10 :1353 , 1984
PubMedID: 6517965

Title : [Interaction of bis-phosphorylated methanes with mammalian esterases] - Makhaeva_1984_Bioorg.Khim_10_1347
Author(s) : Makhaeva GF , Shataeva GA , Iankovskaia VL , Fetisov VI , Loshadkin NA
Ref : Bioorganicheskaia Khimiia , 10 :1347 , 1984
PubMedID: 6517964

Title : [Interaction of various dithio- and thiophosphates containing amino acid fragments with carboxylesterase from rat liver] - Makhaeva_1983_Bioorg.Khim_9_920
Author(s) : Makhaeva GF , Veselova VL , Mastriukova TA , Shipov AE , Zhdanova GV
Ref : Bioorganicheskaia Khimiia , 9 :920 , 1983
PubMedID: 6679786