Speicher_1998_Neuron_20_221

Reference

Title : Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila - Speicher_1998_Neuron_20_221
Author(s) : Speicher S , Garci-Alonso L , Carmena A , Martin-Bermudo MD , de la Escalera S , Jimenez F
Ref : Neuron , 20 :221 , 1998
Abstract :

We have isolated and characterized mutations in Drosophila neurotactin, a gene that encodes a cell adhesion protein widely expressed during neural development. Analysis of both loss and gain of gene function conditions during embryonic and postembryonic development revealed specific requirements for neurotactin during axon outgrowth, fasciculation, and guidance. Furthermore, embryos of some double mutant combinations of neurotactin and other genes encoding adhesion/signaling molecules, including neuroglian, derailed, and kekkon1, displayed phenotypic synergy. This result provides evidence for functional cooperativity in vivo between the adhesion and signaling pathways controlled by neurotactin and the other three genes.

PubMedSearch : Speicher_1998_Neuron_20_221
PubMedID: 9491984

Related information

Family Neurotactin

Citations formats

Speicher S, Garci-Alonso L, Carmena A, Martin-Bermudo MD, de la Escalera S, Jimenez F (1998)
Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila
Neuron 20 :221

Speicher S, Garci-Alonso L, Carmena A, Martin-Bermudo MD, de la Escalera S, Jimenez F (1998)
Neuron 20 :221