| Title : Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function - Sussman_2020_Neuropharmacol__108265 |
| Author(s) : Sussman JL , Silman I |
| Ref : Neuropharmacology , :108265 , 2020 |
|
Abstract :
Computational approaches have proved valuable in elucidating structure/function relationships in the cholinesterases in the context of their unusual three-dimensional structure. In this review we survey several recent studies that have enhanced our understanding of how these enzymes function, and have utilized computational approaches both to modulate their activity and to improve the design of lead compounds for their inhibition. |
| PubMedSearch : Sussman_2020_Neuropharmacol__108265 |
| PubMedID: 32795461 |
Sussman JL, Silman I (2020)
Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function
Neuropharmacology
:108265
Sussman JL, Silman I (2020)
Neuropharmacology
:108265