| Title : Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons - Suzuki_2004_Neurosci.Lett_356_57 |
| Author(s) : Suzuki T , Takagi R , Kawashima K |
| Ref : Neuroscience Letters , 356 :57 , 2004 |
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Abstract :
GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA(A) receptor stimulation and the associated increase in Cl(-) conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABA(A) receptor Cl(-) channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl(-) channel increases neuronal excitability even in an early stage of the development. |
| PubMedSearch : Suzuki_2004_Neurosci.Lett_356_57 |
| PubMedID: 14746901 |
Suzuki T, Takagi R, Kawashima K (2004)
Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons
Neuroscience Letters
356 :57
Suzuki T, Takagi R, Kawashima K (2004)
Neuroscience Letters
356 :57