| Title : Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors - Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| Author(s) : Takahashi J , Hijikuro I , Kihara T , Murugesh MG , Fuse S , Tsumura Y , Akaike A , Niidome T , Takahashi T , Sugimoto H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1721 , 2010 |
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Abstract :
We synthesized carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives 3a-u and evaluated their anti-cholinesterase activities. In vitro evaluation showed that cyclohexylmethylcarbamate derivative 3u potently and selectively inhibits butyrylcholinesterase. |
| PubMedSearch : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| PubMedID: 20137941 |
Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Tsumura Y, Akaike A, Niidome T, Takahashi T, Sugimoto H (2010)
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett
20 :1721
Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Tsumura Y, Akaike A, Niidome T, Takahashi T, Sugimoto H (2010)
Bioorganic & Medicinal Chemistry Lett
20 :1721