Taverni_1998_Brain.Inj_12_77

Reference

Title : Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation - Taverni_1998_Brain.Inj_12_77
Author(s) : Taverni JP , Seliger G , Lichtman SW
Ref : Brain Injury , 12 :77 , 1998
Abstract : Memory dysfunction is a recognized and difficult to treat complication of traumatic brain injury (TBI). Since medial-temporal lobe injury is a frequent contributor to memory dysfunction in TBI, it is likely that an acetylcholine deficit contributes to memory dysfunction in this population. Recently, Donepezil, an acetylcholine-esterase inhibitor which has demonstrated a high selectivity for neural Ach-esterase (with minimal side effects), was approved for use in dementia in Alzheimer's patients. Due to its promising results in Alzheimer's patients, and reports in the literature describing the use of physostigmine (an anti-cholinesterase with significant cardiovascular and autonomic side effects) to treat memory deficits in closed head injury, we decided to begin a trial of Donepezil in two patients with TBI who were experiencing long term static memory dysfunction refractory to conventional treatment. Both patients were admitted to our facility for physical and cognitive rehabilitation, and were started on a trial of Donepezil. Modified memory tests and subjective observations by both family and staff pointed to an improvement in memory within three weeks of starting Donepezil. Should these initial results be supported in larger trials, Donepezil may prove to be a valuable tool for the treatment of memory dysfunction in TBI.
ESTHER : Taverni_1998_Brain.Inj_12_77
PubMedSearch : Taverni_1998_Brain.Inj_12_77
PubMedID: 9483340

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Citations formats

Taverni JP, Seliger G, Lichtman SW (1998)
Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation
Brain Injury 12 :77

Taverni JP, Seliger G, Lichtman SW (1998)
Brain Injury 12 :77