Title : Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins - Telen_1990_Blood_75_1404 |
Author(s) : Telen MJ , Rosse WF , Parker CJ , Moulds MK , Moulds JJ |
Ref : Blood , 75 :1404 , 1990 |
Abstract :
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder associated with absence of expression of phosphatidylinositol (PI)-linked membrane proteins from circulating hematopoietic cells of multiple lineages. Recent work demonstrated that decay accelerating factor, one such PI-linked protein, bears the Cromer-related blood group antigens. This study demonstrated that other high incidence antigens, including Cartwright (Yta/Ytb), Holley-Gregory (Hy/Gya), John Milton Hagen (JMH), and Dombrock (Doa/Dob), are absent from the complement-sensitive (PNH III) erythrocytes of patients with PNH. The relatively normal, complement-insensitive erythrocytes from the same patients express these antigens normally. Therefore, these antigens most likely reside on PI-linked proteins absent from PNH III, but not PNH I, erythrocytes. |
PubMedSearch : Telen_1990_Blood_75_1404 |
PubMedID: 2317557 |
Mutation | H322N_human-ACHE |
Telen MJ, Rosse WF, Parker CJ, Moulds MK, Moulds JJ (1990)
Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins
Blood
75 :1404
Telen MJ, Rosse WF, Parker CJ, Moulds MK, Moulds JJ (1990)
Blood
75 :1404