| Title : A suitable method to monitor inhibition of cholinesterase activities in tissues as induced by reversible enzyme inhibitors - Thomsen_1989_Enzyme_42_219 |
| Author(s) : Thomsen T , Kewitz H , Pleul O |
| Ref : Enzyme , 42 :219 , 1989 |
|
Abstract :
A radiometric method has been used to estimate in vivo activities of cholinesterases in various tissues in the presence of reversible inhibitors. Determination of the samples was performed with the lowest possible degree of dilution to avoid reactivation of the enzyme which would prevent reliable calculation. Dose-response curves and concentration-response curves were performed using physostigmine and tetrahydroacridine, two reversible anticholinesterases in clinical use. Specific inhibition of acetyl- and butyrylcholinesterase was performed using BW284C51 and iso-OMPA, respectively. |
| PubMedSearch : Thomsen_1989_Enzyme_42_219 |
| PubMedID: 2698348 |
Thomsen T, Kewitz H, Pleul O (1989)
A suitable method to monitor inhibition of cholinesterase activities in tissues as induced by reversible enzyme inhibitors
Enzyme
42 :219
Thomsen T, Kewitz H, Pleul O (1989)
Enzyme
42 :219