Tobias_2020_J.Pediatr.Intensive.Care_9_162

Reference

Title : Sugammadex: Applications in Pediatric Critical Care - Tobias_2020_J.Pediatr.Intensive.Care_9_162
Author(s) : Tobias JD
Ref : J Pediatr Intensive Care , 9 :162 , 2020
Abstract :

Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade with a mechanism that differs from acetylcholinesterase inhibitors such as neostigmine. There is a growing body of literature demonstrating its efficacy in pediatric patients of all ages. Prospective trials have demonstrated a more rapid and more complete reversal of rocuronium-induced neuromuscular blockade than the acetylcholinesterase inhibitor, neostigmine. Unlike the acetylcholinesterase inhibitors, sugammadex effectively reverses intense or complete neuromuscular blockade. It may also be effective in situations where reversal of neuromuscular blockade is problematic including patients with neuromyopathic conditions or when acetylcholinesterase inhibitors are contraindicated. This article reviews the physiology of neuromuscular transmission as well as the published literature, regarding the use of sugammadex in pediatric population including the pediatric intensive care unit population. Clinical applications are reviewed, adverse effects are discussed, and dosing algorithms are presented.

PubMedSearch : Tobias_2020_J.Pediatr.Intensive.Care_9_162
PubMedID: 32685243

Related information

Chemical Sugammadex

Citations formats

Tobias JD (2020)
Sugammadex: Applications in Pediatric Critical Care
J Pediatr Intensive Care 9 :162

Tobias JD (2020)
J Pediatr Intensive Care 9 :162