Tobin_2002_Trends.Pharmacol.Sci_23_337

Reference

Title : Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation - Tobin_2002_Trends.Pharmacol.Sci_23_337
Author(s) : Tobin AB
Ref : Trends in Pharmacological Sciences , 23 :337 , 2002
Abstract :

Although originally linked to receptor desensitization, G-protein-coupled receptor (GPCR) phosphorylation has now been implicated in coupling receptors to specific signalling pathways. Generally, this phosphorylation event is thought to be mediated by one of the members of the GPCR kinase (GRK) family. However, recent studies have indicated that protein kinases distinct from the GRK family might also be involved in agonist-mediated GPCR phosphorylation. This review analyses the approaches employed to investigate the nature of GPCR phosphorylation and discusses recent developments implicating other kinases, particularly casein kinase 1 alpha, in the phosphorylation of GPCRs.

PubMedSearch : Tobin_2002_Trends.Pharmacol.Sci_23_337
PubMedID: 12119155

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Citations formats

Tobin AB (2002)
Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation
Trends in Pharmacological Sciences 23 :337

Tobin AB (2002)
Trends in Pharmacological Sciences 23 :337