Turroni_2010_Proc.Natl.Acad.Sci.U.S.A_107_19514

Reference

Title : Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging - Turroni_2010_Proc.Natl.Acad.Sci.U.S.A_107_19514
Author(s) : Turroni F , Bottacini F , Foroni E , Mulder I , Kim JH , Zomer A , Sanchez B , Bidossi A , Ferrarini A , Giubellini V , Delledonne M , Henrissat B , Coutinho P , Oggioni M , Fitzgerald GF , Mills D , Margolles A , Kelly D , van Sinderen D , Ventura M
Ref : Proc Natl Acad Sci U S A , 107 :19514 , 2010
Abstract :

The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.

PubMedSearch : Turroni_2010_Proc.Natl.Acad.Sci.U.S.A_107_19514
PubMedID: 20974960
Gene_locus related to this paper: bifbp-e4nxr0 , bifbp-e4ny70 , bifbp-e4nye9 , bifbp-e4nxi9

Related information

Gene_locus bifbp-e4nxr0    bifbp-e4ny70    bifbp-e4nye9    bifbp-e4nxi9

Citations formats

Turroni F, Bottacini F, Foroni E, Mulder I, Kim JH, Zomer A, Sanchez B, Bidossi A, Ferrarini A, Giubellini V, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Fitzgerald GF, Mills D, Margolles A, Kelly D, van Sinderen D, Ventura M (2010)
Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
Proc Natl Acad Sci U S A 107 :19514

Turroni F, Bottacini F, Foroni E, Mulder I, Kim JH, Zomer A, Sanchez B, Bidossi A, Ferrarini A, Giubellini V, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Fitzgerald GF, Mills D, Margolles A, Kelly D, van Sinderen D, Ventura M (2010)
Proc Natl Acad Sci U S A 107 :19514