Title : Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes - Urani_1995_Toxicol.Lett_76_135 |
Author(s) : Urani C , Chiesara E , Galvani P , Marabini L , Santagostino A , Camatini M |
Ref : Toxicol Lett , 76 :135 , 1995 |
Abstract :
Rat primary hepatocyte cultures have been used to study the effect of Benomyl alone or in combination with Pirimiphos-methyl. The results presented demonstrate that Benomyl alone is responsible for the microtubular disorganization in both a time- and dose-dependent manner, that the effect is reversible after the agent is removed, and that Benomyl is a potent glutathione-depleting agent. Pirimiphos-methyl, alone or combined with Benomyl had no effect on microtubule organization, but reinforced the decrease in glutathione. |
PubMedSearch : Urani_1995_Toxicol.Lett_76_135 |
PubMedID: 7725345 |
Inhibitor | Benomyl Pirimiphos-methyl |
Urani C, Chiesara E, Galvani P, Marabini L, Santagostino A, Camatini M (1995)
Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes
Toxicol Lett
76 :135
Urani C, Chiesara E, Galvani P, Marabini L, Santagostino A, Camatini M (1995)
Toxicol Lett
76 :135