| Title : Formal total synthesis of the polyketide macrolactone narbonolide - Venkatraman_2005_J.Org.Chem_70_7267 |
| Author(s) : Venkatraman L , Aldrich CC , Sherman DH , Fecik RA |
| Ref : J Org Chem , 70 :7267 , 2005 |
|
Abstract :
An improved synthesis of (3S)-3-dihydronarbonolide is reported that constitutes a formal total synthesis of the 14-membered macrolactone antibiotic narbonolide. The key step was an intramolecular Nozaki-Hiyama-Kishi coupling to accomplish macrocyclization in improved yield. The high level of convergence will also allow us to rapidly synthesize narbonolide analogues for the study of enzymes in the pikromycin biosynthetic pathway. |
| PubMedSearch : Venkatraman_2005_J.Org.Chem_70_7267 |
| PubMedID: 16122247 |
Venkatraman L, Aldrich CC, Sherman DH, Fecik RA (2005)
Formal total synthesis of the polyketide macrolactone narbonolide
J Org Chem
70 :7267
Venkatraman L, Aldrich CC, Sherman DH, Fecik RA (2005)
J Org Chem
70 :7267