Vilanova_1999_Crit.Rev.Toxicol_29_21

Reference

Title : The role of phosphotriesterases in the detoxication of organophosphorus compounds - Vilanova_1999_Crit.Rev.Toxicol_29_21
Author(s) : Vilanova E , Sogorb MA
Ref : Crit Rev Toxicol , 29 :21 , 1999
Abstract :

The enzymes that hydrolyze organophosphorus compounds are called phosphotriesterases. The presence of phosphotriesterases has been described in a variety of tissues. The physiological role of these enzymes is not known, although a clear correlation exists between the levels of phosphotriesterases and susceptibility of the species to the toxic effects of organophosphorus compounds. Thus, mammals that possess high levels of phosphotriesterases in serum and liver are more tolerant to the toxic effects of these compounds than birds and insects - these being species considered lacking of phosphotriesterases. Because most of these enzymes are not well characterized, they are usually differentiated according to their different patterns of response to activators and/ or inhibitors. Phosphotriesterases usually depend of divalent cations and therefore EDTA usually inhibits them. A peculiar EDTA-resistant phosphotriesterase has been described in serum albumin. The biotechnological and therapeutical applications of phosphotriesterases are currently subject to study.

PubMedSearch : Vilanova_1999_Crit.Rev.Toxicol_29_21
PubMedID: 10066159

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Citations formats

Vilanova E, Sogorb MA (1999)
The role of phosphotriesterases in the detoxication of organophosphorus compounds
Crit Rev Toxicol 29 :21

Vilanova E, Sogorb MA (1999)
Crit Rev Toxicol 29 :21