Vivas_1993_Eur.J.Pharmacol_245_9

Reference

Title : Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system - Vivas_1993_Eur.J.Pharmacol_245_9
Author(s) : Vivas NM , Badia A , Marmol F , Dierssen M
Ref : European Journal of Pharmacology , 245 :9 , 1993
Abstract :

The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on beta-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 microM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 +/- 0.13 microM) and hippocampal (IC50 = 0.02 +/- 0.003 microM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the beta-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function.

PubMedSearch : Vivas_1993_Eur.J.Pharmacol_245_9
PubMedID: 8386672

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Citations formats

Vivas NM, Badia A, Marmol F, Dierssen M (1993)
Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system
European Journal of Pharmacology 245 :9

Vivas NM, Badia A, Marmol F, Dierssen M (1993)
European Journal of Pharmacology 245 :9