Title : Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice - Vujic_2015_Atherosclerosis_244_9 |
Author(s) : Vujic N , Schlager S , Eichmann TO , Madreiter-Sokolowski CT , Goeritzer M , Rainer S , Schauer S , Rosenberger A , Woelfler A , Doddapattar P , Zimmermann R , Hoefler G , Lass A , Graier WF , Radovic B , Kratky D |
Ref : Atherosclerosis , 244 :9 , 2015 |
Abstract :
BACKGROUND AND AIMS: Monoglyceride lipase (MGL) catalyzes the final step of lipolysis by degrading monoglyceride (MG) to glycerol and fatty acid. MGL also hydrolyzes and thereby deactivates 2-arachidonoyl glycerol (2-AG), the most abundant endocannabinoid in the mammalian system. 2-AG acts as full agonist on cannabinoid receptor type 1 (CB1R) and CB2R, which are mainly expressed in brain and immune cells, respectively. Thus, we speculated that in the absence of MGL, increased 2-AG concentrations mediate CB2R signaling in immune cells to modulate inflammatory responses, thereby affecting the development of atherosclerosis. METHODS AND |
PubMedSearch : Vujic_2015_Atherosclerosis_244_9 |
PubMedID: 26584135 |
Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D (2015)
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice
Atherosclerosis
244 :9
Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D (2015)
Atherosclerosis
244 :9