| Title : Inhibitory effects of quinidine on rat heart muscarinic receptors - Waelbroeck_1984_Life.Sci_35_1069 |
| Author(s) : Waelbroeck M , de Neef P , Robberecht P , Christophe J |
| Ref : Life Sciences , 35 :1069 , 1984 |
|
Abstract :
Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M [( 3H]Oxo-M) and the labelled antagonist [3H]N-methylscopolamine [( 3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates (I50: 4 and 7.5 microM) and dissociation rates (I50: 100 and 68 microM) of [3H]Oxo-M and [3H]NMS, with different potencies. These cooperative effects explained the low Hill coefficients and apparent selectivity of quinidine competition curves. |
| PubMedSearch : Waelbroeck_1984_Life.Sci_35_1069 |
| PubMedID: 6482646 |
Waelbroeck M, de Neef P, Robberecht P, Christophe J (1984)
Inhibitory effects of quinidine on rat heart muscarinic receptors
Life Sciences
35 :1069
Waelbroeck M, de Neef P, Robberecht P, Christophe J (1984)
Life Sciences
35 :1069