| Title : 80\% of muscarinic receptors expressed by the NB-OK 1 human neuroblastoma cell line show high affinity for pirenzepine and are comparable to rat hippocampus M1 receptors - Waelbroeck_1988_FEBS.Lett_226_287 |
| Author(s) : Waelbroeck M , Camus J , Tastenoy M , Christophe J |
| Ref : FEBS Letters , 226 :287 , 1988 |
|
Abstract :
The NB-OK 1 human neuroblastoma cell line expressed muscarinic cholinergic receptors that could be labeled with N-[3H]methylscopolamine (a nonselective antagonist). 80% of these receptors showed high affinity for pirenzepine, i.e. belonged to the M 1 subtype found in neuronal tissues. Their binding properties were identical to those of rat hippocampus M 1 receptors, and differed from those of rat pancreas and heart muscarinic receptors. The remaining (20%) muscarinic receptors showed low affinity for pirenzepine and AF-DX 116, being therefore of an M2 beta (or B) subtype, and were similar to rat pancreatic receptors. |
| PubMedSearch : Waelbroeck_1988_FEBS.Lett_226_287 |
| PubMedID: 3338559 |
Waelbroeck M, Camus J, Tastenoy M, Christophe J (1988)
80\% of muscarinic receptors expressed by the NB-OK 1 human neuroblastoma cell line show high affinity for pirenzepine and are comparable to rat hippocampus M1 receptors
FEBS Letters
226 :287
Waelbroeck M, Camus J, Tastenoy M, Christophe J (1988)
FEBS Letters
226 :287