| Title : Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists - Wang_2002_Bioorg.Med.Chem.Lett_12_1087 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , McKittrick BA , Greenlee W , Ruperto V , Duffy RA , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1087 , 2002 |
|
Abstract :
We have discovered highly potent, selective sulfide M(2) receptor antagonists with low molecular weight and different structural features compared with our phase I clinical candidate Sch 211803. Analogue 30 showed superior M(2) receptor selectivity profile over Sch 211803. More importantly, this study provided new leads for the discovery of M(2) receptor antagonists as potential drug candidates. |
| PubMedSearch : Wang_2002_Bioorg.Med.Chem.Lett_12_1087 |
| PubMedID: 11909724 |
Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE (2002)
Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists
Bioorganic & Medicinal Chemistry Lett
12 :1087
Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE (2002)
Bioorganic & Medicinal Chemistry Lett
12 :1087