Full name : Lachowicz Jean E
First name : Jean E
Mail : Department of Medicinal Chemistry and Metabolic Disorders, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
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Country : USA
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Comment
| Title : Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity - Clader_2004_Bioorg.Med.Chem_12_319 |
| Author(s) : Clader JW , Billard W , Binch H, 3rd , Chen LY , Crosby G, Jr. , Duffy RA , Ford J , Kozlowski JA , Lachowicz JE , Li S , Liu C , McCombie SW , Vice S , Zhou G , Greenlee WJ |
| Ref : Bioorganic & Medicinal Chemistry , 12 :319 , 2004 |
| Abstract : |
| PubMedSearch : Clader_2004_Bioorg.Med.Chem_12_319 |
| PubMedID: 14723952 |
| Title : Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists - Palani_2004_Bioorg.Med.Chem.Lett_14_1791 |
| Author(s) : Palani A , Dugar S , Clader JW , Greenlee WJ , Ruperto V , Duffy RA , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1791 , 2004 |
| Abstract : |
| PubMedSearch : Palani_2004_Bioorg.Med.Chem.Lett_14_1791 |
| PubMedID: 15026073 |
| Title : Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists - Wang_2002_J.Med.Chem_45_5415 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Greenlee WJ , Clader J , Boyle CD , Kaminski JJ , Billard W , Binch H, 3rd , Crosby G , Ruperto V , Duffy RA , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Lachowicz JE |
| Ref : Journal of Medicinal Chemistry , 45 :5415 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_J.Med.Chem_45_5415 |
| PubMedID: 12459007 |
| Title : Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists - Wang_2002_Bioorg.Med.Chem.Lett_12_1087 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , McKittrick BA , Greenlee W , Ruperto V , Duffy RA , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1087 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_Bioorg.Med.Chem.Lett_12_1087 |
| PubMedID: 11909724 |
| Title : Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification - Boyle_2002_Bioorg.Med.Chem.Lett_12_3479 |
| Author(s) : Boyle CD , Vice SF , Campion J , Chackalamannil S , Lankin CM , McCombie SW , Billard W , Binch H, 3rd , Crosby G , Williams MC , Coffin VL , Cox KA , Grotz DE , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :3479 , 2002 |
| Abstract : |
| PubMedSearch : Boyle_2002_Bioorg.Med.Chem.Lett_12_3479 |
| PubMedID: 12419388 |
| Title : Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands - Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| Author(s) : Kozlowski JA , Zhou G , Tagat JR , Lin SI , McCombie SW , Ruperto VB , Duffy RA , McQuade RA , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :791 , 2002 |
| Abstract : |
| PubMedSearch : Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| PubMedID: 11859004 |
| Title : Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family - McCombie_2002_Bioorg.Med.Chem.Lett_12_795 |
| Author(s) : McCombie SW , Lin SI , Tagat JR , Nazareno D , Vice S , Ford J , Asberom T , Leone D , Kozlowski JA , Zhou G , Ruperto VB , Duffy RA , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :795 , 2002 |
| Abstract : |
| PubMedSearch : McCombie_2002_Bioorg.Med.Chem.Lett_12_795 |
| PubMedID: 11859005 |
| Title : Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution - Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| Author(s) : Boyle CD , Chackalamannil S , Clader JW , Greenlee WJ , Josien HB , Kaminski JJ , Kozlowski JA , McCombie SW , Nazareno DV , Tagat JR , Wang Y , Zhou G , Billard W , Binch H , Crosby G , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :2311 , 2001 |
| Abstract : |
| PubMedSearch : Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| PubMedID: 11527721 |
| Title : Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788 - Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| Author(s) : Lachowicz JE , Duffy RA , Ruperto V , Kozlowski J , Zhou G , Clader J , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Strader CD , Coffin V |
| Ref : Life Sciences , 68 :2585 , 2001 |
| Abstract : |
| PubMedSearch : Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| PubMedID: 11392630 |
| Title : Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists - Wang_2001_Bioorg.Med.Chem.Lett_11_891 |
| Author(s) : Wang Y , Chackalamannil S , Chang W , Greenlee W , Ruperto V , Duffy RA , McQuade R , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :891 , 2001 |
| Abstract : |
| PubMedSearch : Wang_2001_Bioorg.Med.Chem.Lett_11_891 |
| PubMedID: 11294385 |
| Title : Benzylidene ketal derivatives as M2 muscarinic receptor antagonists - Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| Author(s) : Boyle CD , Chackalamannil S , Chen LY , Dugar S , Pushpavanam P , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Coffin VL , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2727 , 2000 |
| Abstract : |
| PubMedSearch : Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| PubMedID: 11133078 |
| Title : Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor - Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| Author(s) : Kozlowski JA , Lowe DB , Guzik HS , Zhou G , Ruperto VB , Duffy RA , McQuade R , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2255 , 2000 |
| Abstract : |
| PubMedSearch : Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| PubMedID: 11055332 |
| Title : Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists - Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Clader JW , Greenlee W , Billard W , Binch H , Crosby G , Ruperto V , Duffy RA , McQuade R , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2247 , 2000 |
| Abstract : |
| PubMedSearch : Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| PubMedID: 11055330 |
| Title : SCH 57790: a novel M2 receptor selective antagonist - Lachowicz_1999_Life.Sci_64(6-7)_535 |
| Author(s) : Lachowicz JE , Lowe D , Duffy RA , Ruperto V , Taylor LA , Guzik H , Brown J , Berger JG , Tice M , McQuade R , Kozlowski J , Clader J , Strader CD , Murgolo N |
| Ref : Life Sciences , 64 :535 , 1999 |
| Abstract : |
| PubMedSearch : Lachowicz_1999_Life.Sci_64(6-7)_535 |
| PubMedID: 10069520 |