| Title : Novel alkaloids from the roots of Stemona sessilifolia - Wang_2007_Chem.Biodivers_4_523 |
| Author(s) : Wang P , Liu AL , An Z , Li ZH , Du GH , Qin HL |
| Ref : Chem Biodivers , 4 :523 , 2007 |
|
Abstract :
Four new Stemona alkaloids, sessilistemonamines A-C (1-3, resp.) and dihydrostemoninine (4), were isolated from the roots of Stemona sessilifolia. Their structures and relative configurations were elucidated by means of in-depth 1D- and 2D-NMR-spectroscopic as well as mass-spectrometric experiments; and the structure of 4 was solved by X-ray single-crystal diffraction. The stereoisomeric compounds 1-3 share an unprecedented tetracyclic decahydro-1H-furo[2',3':4,5]cyclopenta[1,2-b]pyrrolo[1,2-a]azepine nucleus. Compounds 1 and 2 were found to be moderately active in terms of acetylcholinesterase (AchE) inhibition, with IC50 values of 68.8+/-9.5 and 17.1+/-2.5 microM, resp. |
| PubMedSearch : Wang_2007_Chem.Biodivers_4_523 |
| PubMedID: 17372955 |
Wang P, Liu AL, An Z, Li ZH, Du GH, Qin HL (2007)
Novel alkaloids from the roots of Stemona sessilifolia
Chem Biodivers
4 :523
Wang P, Liu AL, An Z, Li ZH, Du GH, Qin HL (2007)
Chem Biodivers
4 :523