Title : Protein liposomes-mediated targeted acetylcholinesterase gene delivery for effective liver cancer therapy - Wang_2021_J.Nanobiotechnology_19_31 |
Author(s) : Wang K , Shang F , Chen D , Cao T , Wang X , Jiao J , He S , Liang X |
Ref : J Nanobiotechnology , 19 :31 , 2021 |
Abstract :
BACKGROUND: Effective methods to deliver therapeutic genes to solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development of efficient non-viral gene vector with tumor-targeting has very important application value in the field of cancer therapy. Proteolipid integrated with tumor-targeting potential of functional protein and excellent gene delivery performance has shown potential for targeted gene therapy. RESULTS: Herein, we prepared transferrin-modified liposomes (Tf-PL) for the targeted delivery of acetylcholinesterase (AChE) therapeutic gene to liver cancer. We found that the derived Tf-PL/AChE liposomes exhibited much higher transfection efficiency than the commercial product Lipo 2000 and shown premium targeting efficacy to liver cancer SMMC-7721 cells in vitro. In vivo, the Tf-PL/AChE could effectively target liver cancer, and significantly inhibit the growth of liver cancer xenografts grafted in nude mice by subcutaneous administration. CONCLUSIONS: This study proposed a transferrin-modified proteolipid-mediated gene delivery strategy for targeted liver cancer treatment, which has a promising potential for precise personalized cancer therapy. |
PubMedSearch : Wang_2021_J.Nanobiotechnology_19_31 |
PubMedID: 33482834 |
Wang K, Shang F, Chen D, Cao T, Wang X, Jiao J, He S, Liang X (2021)
Protein liposomes-mediated targeted acetylcholinesterase gene delivery for effective liver cancer therapy
J Nanobiotechnology
19 :31
Wang K, Shang F, Chen D, Cao T, Wang X, Jiao J, He S, Liang X (2021)
J Nanobiotechnology
19 :31