Title : Chylomicronemia elicits atherosclerosis in mice--brief report - Weinstein_2010_Arterioscler.Thromb.Vasc.Biol_30_20 |
Author(s) : Weinstein MM , Yin L , Tu Y , Wang X , Wu X , Castellani LW , Walzem RL , Lusis AJ , Fong LG , Beigneux AP , Young SG |
Ref : Arterioscler Thromb Vasc Biol , 30 :20 , 2010 |
Abstract :
OBJECTIVE: The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. METHODS AND RESULTS: Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins. CONCLUSIONS: Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins. |
PubMedSearch : Weinstein_2010_Arterioscler.Thromb.Vasc.Biol_30_20 |
PubMedID: 19815815 |
Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG (2010)
Chylomicronemia elicits atherosclerosis in mice--brief report
Arterioscler Thromb Vasc Biol
30 :20
Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG (2010)
Arterioscler Thromb Vasc Biol
30 :20