| Title : Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts - Wieczorek_2011_Tetrahedron.Lett_52_1601 |
| Author(s) : Wieczorek B , Traff A , Krumlinde P , Dijkstra HP , Egmond MR , van Koten G , Backvall JE , Klein Gebbink RJ |
| Ref : Tetrahedron Letters , 52 :1601 , 2011 |
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Abstract :
The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol. |
| PubMedSearch : Wieczorek_2011_Tetrahedron.Lett_52_1601 |
| PubMedID: |
| Gene_locus related to this paper: canar-LipB , fusso-cutas |
| Inhibitor | ArM-Rhubidium-cofactor-8 |
| Gene_locus | canar-LipB fusso-cutas |
Wieczorek B, Traff A, Krumlinde P, Dijkstra HP, Egmond MR, van Koten G, Backvall JE, Klein Gebbink RJ (2011)
Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts
Tetrahedron Letters
52 :1601
Wieczorek B, Traff A, Krumlinde P, Dijkstra HP, Egmond MR, van Koten G, Backvall JE, Klein Gebbink RJ (2011)
Tetrahedron Letters
52 :1601