Winrow_2003_Nat.Genet_33_477

Reference

Title : Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity - Winrow_2003_Nat.Genet_33_477
Author(s) : Winrow CJ , Hemming ML , Allen DM , Quistad GB , Casida JE , Barlow C
Ref : Nat Genet , 33 :477 , 2003
Abstract :

Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. We generated mice with disruptions in Nte, the gene encoding NTE. Nte(-/-) mice die after embryonic day 8, and Nte(+/-) mice have lower activity of Nte in the brain and higher mortality when exposed to the Nte-inhibiting compound ethyl octylphosphonofluoridate (EOPF) than do wild-type mice. Nte(+/-) and wild-type mice treated with 1 mg per kg of body weight of EOPF have elevated motor activity, showing that even minor reduction of Nte activity leads to hyperactivity. These studies show that genetic or chemical reduction of Nte activity results in a neurological phenotype of hyperactivity in mammals and indicate that EOPF toxicity occurs directly through inhibition of Nte without the requirement for Nte gain of function or aging.

PubMedSearch : Winrow_2003_Nat.Genet_33_477
PubMedID: 12640454

Related information

Inhibitor EOPF

Citations formats

Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003)
Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity
Nat Genet 33 :477

Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003)
Nat Genet 33 :477