EOPF
Inhibitor of NTE (neurotoxic esterase), PNPLA6 (not an alpha beta hydrolase) FAAH (not an alpha beta hydrolase)
General
Type : Organophosphate, NTE inhibitor, Not A\/B H target, FAAH inhibitor
Chemical_Nomenclature : 1-[ethoxy(fluoro)phosphoryl]octane
Canonical SMILES : CCCCCCCCP(=O)(OCC)F
InChI : InChI=1S\/C10H22FO2P\/c1-3-5-6-7-8-9-10-14(11,12)13-4-2\/h3-10H2,1-2H3
InChIKey : QXGGCRMRWONSSB-UHFFFAOYSA-N
Other name(s) : ethyl octylphosphonofluoridate || SCHEMBL1259200 || CTK0A7987 || Phosphonofluoridic acid, octyl-, ethyl ester
MW : 224.25
Formula : C10H22FO2P
CAS_number : 171741-11-0
PubChem : 21080074
UniChem : QXGGCRMRWONSSB-UHFFFAOYSA-N
Target
References (7)
| Title : Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase - Read_2010_Toxicol.Appl.Pharmacol_245_108 |
| Author(s) : Read DJ , Li Y , Chao MV , Cavanagh JB , Glynn P |
| Ref : Toxicol Appl Pharmacol , 245 :108 , 2010 |
| Abstract : |
| PubMedSearch : Read_2010_Toxicol.Appl.Pharmacol_245_108 |
| PubMedID: 20188121 |
| Title : Lysophospholipase inhibition by organophosphorus toxicants - Quistad_2004_Toxicol.Appl.Pharmacol_196_319 |
| Author(s) : Quistad GB , Casida JE |
| Ref : Toxicol Appl Pharmacol , 196 :319 , 2004 |
| Abstract : |
| PubMedSearch : Quistad_2004_Toxicol.Appl.Pharmacol_196_319 |
| PubMedID: 15094302 |
| Title : Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets - |
| Author(s) : Casida JE , Quistad GB |
| Ref : Chemical Research in Toxicology , 17 :983 , 2004 |
| PubMedID: 15310231 |
| Title : Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity - Winrow_2003_Nat.Genet_33_477 |
| Author(s) : Winrow CJ , Hemming ML , Allen DM , Quistad GB , Casida JE , Barlow C |
| Ref : Nat Genet , 33 :477 , 2003 |
| Abstract : |
| PubMedSearch : Winrow_2003_Nat.Genet_33_477 |
| PubMedID: 12640454 |
| Title : Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides - Quistad_2001_Toxicol.Appl.Pharmacol_173_48 |
| Author(s) : Quistad GB , Sparks SE , Casida JE |
| Ref : Toxicol Appl Pharmacol , 173 :48 , 2001 |
| Abstract : |
| PubMedSearch : Quistad_2001_Toxicol.Appl.Pharmacol_173_48 |
| PubMedID: 11350214 |
| Title : Actions of two highly potent organophosphorus neuropathy target esterase inhibitors in mammalian cell lines - Li_1997_Toxicol.Lett_92_123 |
| Author(s) : Li W , Casida JE |
| Ref : Toxicol Lett , 92 :123 , 1997 |
| Abstract : |
| PubMedSearch : Li_1997_Toxicol.Lett_92_123 |
| PubMedID: 9295235 |
| Title : Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors - Wu_1996_Toxicol.Appl.Pharmacol_139_195 |
| Author(s) : Wu SY , Casida JE |
| Ref : Toxicology & Applied Pharmacology , 139 :195 , 1996 |
| Abstract : |
| PubMedSearch : Wu_1996_Toxicol.Appl.Pharmacol_139_195 |
| PubMedID: 8685903 |