EOPF

Inhibitor of NTE (neurotoxic esterase), PNPLA6 (not an alpha beta hydrolase) FAAH (not an alpha beta hydrolase)

General

Type : Organophosphate, NTE inhibitor, Not A\/B H target, FAAH inhibitor

Chemical_Nomenclature : 1-[ethoxy(fluoro)phosphoryl]octane

Canonical SMILES : CCCCCCCCP(=O)(OCC)F

InChI : InChI=1S\/C10H22FO2P\/c1-3-5-6-7-8-9-10-14(11,12)13-4-2\/h3-10H2,1-2H3

InChIKey : QXGGCRMRWONSSB-UHFFFAOYSA-N

Other name(s) : ethyl octylphosphonofluoridate, SCHEMBL1259200, CTK0A7987, Phosphonofluoridic acid, octyl-, ethyl ester


MW : 224.25

Formula : C10H22FO2P

CAS_number : 171741-11-0

PubChem : 21080074

UniChem : QXGGCRMRWONSSB-UHFFFAOYSA-N

Target

References (7)

Title : Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase - Read_2010_Toxicol.Appl.Pharmacol_245_108
Author(s) : Read DJ , Li Y , Chao MV , Cavanagh JB , Glynn P
Ref : Toxicol Appl Pharmacol , 245 :108 , 2010
PubMedID: 20188121

Title : Lysophospholipase inhibition by organophosphorus toxicants - Quistad_2004_Toxicol.Appl.Pharmacol_196_319
Author(s) : Quistad GB , Casida JE
Ref : Toxicol Appl Pharmacol , 196 :319 , 2004
PubMedID: 15094302

Title : Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets -
Author(s) : Casida JE , Quistad GB
Ref : Chemical Research in Toxicology , 17 :983 , 2004
PubMedID: 15310231

Title : Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity - Winrow_2003_Nat.Genet_33_477
Author(s) : Winrow CJ , Hemming ML , Allen DM , Quistad GB , Casida JE , Barlow C
Ref : Nat Genet , 33 :477 , 2003
PubMedID: 12640454

Title : Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides - Quistad_2001_Toxicol.Appl.Pharmacol_173_48
Author(s) : Quistad GB , Sparks SE , Casida JE
Ref : Toxicol Appl Pharmacol , 173 :48 , 2001
PubMedID: 11350214

Title : Actions of two highly potent organophosphorus neuropathy target esterase inhibitors in mammalian cell lines - Li_1997_Toxicol.Lett_92_123
Author(s) : Li W , Casida JE
Ref : Toxicol Lett , 92 :123 , 1997
PubMedID: 9295235

Title : Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors - Wu_1996_Toxicol.Appl.Pharmacol_139_195
Author(s) : Wu SY , Casida JE
Ref : Toxicology & Applied Pharmacology , 139 :195 , 1996
PubMedID: 8685903