Wion_1987_Science_235_1638

Reference

Title : Human lipoprotein lipase complementary DNA sequence - Wion_1987_Science_235_1638
Author(s) : Wion KL , Kirchgessner TG , Lusis AJ , Schotz MC , Lawn RM
Ref : Science , 235 :1638 , 1987
Abstract :

Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins. It has been proposed that the enzyme plays a role in the development of obesity and atherosclerosis. The human enzyme has been difficult to purify and its protein sequence was heretofore undetermined. A complementary DNA for human lipoprotein lipase that codes for a mature protein of 448 amino acids has now been cloned and sequenced. Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family. Two distinct species of lipoprotein lipase messenger RNA that arise from alternative sites of 3'-terminal polyadenylation were detected in several different tissues.

PubMedSearch : Wion_1987_Science_235_1638
PubMedID: 3823907
Gene_locus related to this paper: human-LPL

Related information

Citations formats

Wion KL, Kirchgessner TG, Lusis AJ, Schotz MC, Lawn RM (1987)
Human lipoprotein lipase complementary DNA sequence
Science 235 :1638

Wion KL, Kirchgessner TG, Lusis AJ, Schotz MC, Lawn RM (1987)
Science 235 :1638