Wolkmer_2012_Parasitol.Int_62_144

Reference

Title : Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi - Wolkmer_2012_Parasitol.Int_62_144
Author(s) : Wolkmer P , da Silva CB , Paim FC , Duarte MM , Castro V , Palma HE , Franca RT , Felin DV , Siqueira LC , Lopes ST , Schetinger MR , Monteiro SG , Mazzanti CM
Ref : Parasitol Int , 62 :144 , 2012
Abstract :

The potent activity against Trypanosomes and health beneficial effects of curcumin (Cur) has been demonstrated in various experimental models. In this study, we evaluated the in vivo effect of Cur as trypanocide and as potential anti-inflammatory agent, through the evaluation of immunomodulatory mechanisms in rats infected with Trypanosoma evansi. Daily oral Cur was administered at doses of 0, 20 or 60mg/kg as preventive treatment (30 and 15days pre infection) and as treatment (post infection). The treatment of the groups continued until the day of euthanasia. Fifteen days after inoculation, parasitemia, plasma proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-1, IL-6), anti-inflammatory cytokines (IL-10) and blood acetylcholinesterase activity (AChE) were analyzed. Pretreatment with Cur reduced parasitemia and lethality. Cur inhibited AChE activity and improved immunological response by cytokines proinflammatory, fundamental during T. evansi infection. We found that Cur is not so important as an antitrypanosomal activity but as immunomodulator agent. These findings reveal that the preventive use of Cur stimulates anti-inflammatory mechanisms, reducing an excessive inflammatory response.

PubMedSearch : Wolkmer_2012_Parasitol.Int_62_144
PubMedID: 23200738

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Citations formats

Wolkmer P, da Silva CB, Paim FC, Duarte MM, Castro V, Palma HE, Franca RT, Felin DV, Siqueira LC, Lopes ST, Schetinger MR, Monteiro SG, Mazzanti CM (2012)
Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi
Parasitol Int 62 :144

Wolkmer P, da Silva CB, Paim FC, Duarte MM, Castro V, Palma HE, Franca RT, Felin DV, Siqueira LC, Lopes ST, Schetinger MR, Monteiro SG, Mazzanti CM (2012)
Parasitol Int 62 :144