| Title : Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening - Xiong_2021_Bioorg.Med.Chem.Lett__127986 |
| Author(s) : Xiong F , Ding X , Zhang H , Luo X , Chen K , Jiang H , Luo C , Xu H |
| Ref : Bioorganic & Medicinal Chemistry Lett , :127986 , 2021 |
|
Abstract :
Monoacylglycerol lipase (MAGL) is the major enzyme that catalyzes the hydrolysis of monoacylglycerols (MAGs). MAGL is responsible for degrading 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain and specific tissues. The inhibition of MAGL could attenuate the inflammatory response. Here, we report a series of reversible non-covalent MAGL inhibitors via virtual screening combined with biochemical analysis. The hit, DC630-8 showed low-micromolar activity against MAGL in vitro, and exhibited significant anti-inflammatory effects. |
| PubMedSearch : Xiong_2021_Bioorg.Med.Chem.Lett__127986 |
| PubMedID: 33766770 |
| Gene_locus related to this paper: human-MGLL |
| Gene_locus | human-MGLL |
Xiong F, Ding X, Zhang H, Luo X, Chen K, Jiang H, Luo C, Xu H (2021)
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening
Bioorganic & Medicinal Chemistry Lett
:127986
Xiong F, Ding X, Zhang H, Luo X, Chen K, Jiang H, Luo C, Xu H (2021)
Bioorganic & Medicinal Chemistry Lett
:127986