| Title : Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors - Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| Author(s) : Xu J , Wei L , Mathvink R , He J , Park YJ , He H , Leiting B , Lyons KA , Marsilio F , Patel RA , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2533 , 2005 |
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Abstract :
anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. These are among the most potent compounds reported to date lacking an electrophilic trap. The most potent compound among these is 5-oxo-1,2,4-oxadiazole 44, which is a 3 nM DPP-IV inhibitor. |
| PubMedSearch : Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| PubMedID: 15863311 |
Xu J, Wei L, Mathvink R, He J, Park YJ, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Wu JK, Thornberry NA, Weber AE (2005)
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
15 :2533
Xu J, Wei L, Mathvink R, He J, Park YJ, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Wu JK, Thornberry NA, Weber AE (2005)
Bioorganic & Medicinal Chemistry Lett
15 :2533