| Title : Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1 - Xu_2010_Nat.Neurosci_13_22 |
| Author(s) : Xu J , Xiao N , Xia J |
| Ref : Nat Neurosci , 13 :22 , 2010 |
|
Abstract :
In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons. |
| PubMedSearch : Xu_2010_Nat.Neurosci_13_22 |
| PubMedID: 19915562 |
Xu J, Xiao N, Xia J (2010)
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Nat Neurosci
13 :22
Xu J, Xiao N, Xia J (2010)
Nat Neurosci
13 :22