| Title : Effects of Di-n-butyl Phthalate and Diethyl Phthalate on Acetylcholinesterase Activity and Neurotoxicity Related Gene Expression in Embryonic Zebrafish - Xu_2013_Bull.Environ.Contam.Toxicol_91_635 |
| Author(s) : Xu H , Shao X , Zhang Z , Zou Y , Chen Y , Han S , Wang S , Wu X , Yang L , Chen Z |
| Ref : Bulletin of Environmental Contamination & Toxicology , 91 :635 , 2013 |
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Abstract :
In the present study, zebrafish embryos were used to assess the neurotoxicity of di-n-butyl phthalate (DBP), diethyl phthalate (DEP) and their mixture. Four-hour post-fertilization (hpf) zebrafish embryos were exposed to various concentrations of DBP, DEP and their mixture (DBP-DEP) until 96 hpf. The transcriptions levels of selected neuron-related genes reported as neurotoxicity biomarkers were analyzed. The results showed that transcripts of growth associated protein 43 (gap43), embryonic lethal abnormal vision-like 3 (elavl3), glial fibrillary acidic protein (gfap), myelin basic protein (mbp), alpha1-tubulin and neurogenin1 (ngn1) were significantly up-regulated after DBP, DEP and DBP-DEP mixture exposure. In addition, acetylcholinesterase activity was significantly inhibited in the embryos. These results indicate that DBP and DEP have the potential neurotoxicity in zebrafish embryos. |
| PubMedSearch : Xu_2013_Bull.Environ.Contam.Toxicol_91_635 |
| PubMedID: 24042840 |
| Gene_locus related to this paper: danre-ACHE |
| Gene_locus | danre-ACHE |
Xu H, Shao X, Zhang Z, Zou Y, Chen Y, Han S, Wang S, Wu X, Yang L, Chen Z (2013)
Effects of Di-n-butyl Phthalate and Diethyl Phthalate on Acetylcholinesterase Activity and Neurotoxicity Related Gene Expression in Embryonic Zebrafish
Bulletin of Environmental Contamination & Toxicology
91 :635
Xu H, Shao X, Zhang Z, Zou Y, Chen Y, Han S, Wang S, Wu X, Yang L, Chen Z (2013)
Bulletin of Environmental Contamination & Toxicology
91 :635